Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men
Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men
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DOI：
10.1210/jc.2007-1217
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发表时间：
2008-01-01
影响因子：
5.8
通讯作者：
Holick, Michael F.
中科院分区：
文献类型：
--
作者：
Hannan, Marian T.;Litman, Heather J.;Holick, Michael F.
内容：虽然维生素D状态和骨密度（BMD）的种族和民族差异是公认的，但维生素D状态的差异如何影响BMD，特别是在男性中，却知之甚少。目的：我们的目的是研究血清25-羟基维生素D [25（OH）D]与不同种族和民族的BMD之间的关系。设计：我们进行了一项以人群为基础的观察性调查。参与者：参与者包括1114名黑人、西班牙裔和白色男性，年龄30-79岁。结果：我们通过竞争性蛋白结合试验评估25（OH）D，通过双能X射线吸收测定法评估BMD。结果：331名黑人、362名西班牙裔和421名白色男性的平均年龄+/- SD为48 +/- 12.8岁。与白色男性（37.4 +/-14.0 ng/ml，P < 0.01）相比，黑人男性（25.0 +/- 14.7 ng/ml）和西班牙裔男性（32.9 +/- 13.9 ng/ml）的平均25（OH）D较低。黑人男性（44%）和西班牙裔男性（23%）中25（OH）D水平处于最低四分位数的比例较高，而白色男性的这一比例为11%（P < 0.001）。校正年龄、身高和体重后，只有白色男性显示25（OH）D和BMD之间存在显著正相关（相关范围为0.00-0.14）。血清25（OH）D与黑人或西班牙裔男性任何骨部位的BMD无关。结果是相似的，调整后的年龄ONLY. CONCLUSION：我们的研究结果证实，在男性的BMD和血清25（OH）D的实质性种族和民族的差异。血清25（OH）D和BMD仅在白色男性中显著相关。这可能对低水平25（OH）D男性的骨骼健康和补充剂的评估有影响。需要进一步了解种族和族裔群体之间这些差异的生物学机制。
Context: Although racial and ethnic differences in vitamin D status and bone mineral density (BMD) are recognized, less is known about how differences in vitamin D status impact BMD, especially among men.Objective: Our objective was to examine the relation between serum 25-hydroxyvitamin D [25(OH)D] and BMD by race and ethnic group.Design: We conducted a population-based, observational survey.Participants: Participants included 1114 Black, Hispanic, and White men, 30-79 yr of age.Outcomes: We assessed 25(OH)D by a competitive protein binding assay and BMD by dual-energy x-ray absorptiometry.Results: Mean age +/- SD of the 331 Black, 362 Hispanic, and 421 White men was 48 +/- 12.8 yr. Mean 25(OH)D was lower among Black (25.0 +/- 14.7 ng/ml) and Hispanic (32.9 +/- 13.9 ng/ml) men compared with White men (37.4 +/- 14.0 ng/ml, P < 0.01). A higher percentage of both Black (44%) and Hispanic (23%) men had levels of 25(OH)D in the lowest quartile, compared with 11% of White men (P < 0.001). After adjusting for age, height, and weight, only White men showed significant positive correlation between 25(OH)D and BMD (range of correlations, 0.00-0.14). Serum 25(OH)D was not associated with BMD in Black or Hispanic men at any bone site. Results were similar when adjusted for age only.Conclusions: Our findings confirm substantial racial and ethnic group differences in BMD and serum 25(OH)D in men. Serum 25(OH)D and BMD are significantly related to one another in White men only. This may have implications for evaluation of bone health and supplementation in men with low levels of 25(OH)D. Further understanding of the biological mechanisms for these differences between race and ethnic groups is needed.