FEAR AND MODIFICATION OF ACOUSTICALLY EVOKED POTENTIALS DURING CONDITIONING
FEAR AND MODIFICATION OF ACOUSTICALLY EVOKED POTENTIALS DURING CONDITIONING
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DOI：
10.1152/jn.1967.30.4.893
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发表时间：
1967-01-01
影响因子：
2.5
通讯作者：
MARK, RG
中科院分区：
文献类型：
--
作者：
HALL, RD;MARK, RG
进行实验以确定运动是否对大鼠在条件反射过程中观察到的声诱发电位变化负责。其中一种方法是通过电刺激耳蜗核或耳蜗来激发听觉电位，绕过运动过程中运行的外周听觉机制，通过光条件刺激（CS）建立条件情绪反应。在另一项研究中，通过行为技术和在不运动期间取样点击诱发电位来消除控制和光CS条件下的运动差异。在这两种情况下，从听觉皮层、内侧膝状体和下碰撞体记录的电位晚期分量的振幅与条件情绪反应的强度直接相关。这些反应的早期成分和耳蜗腹侧核的反应没有显示出这种关系。非条件恐惧也伴随着诱发电位振幅的增加。在厌恶条件反射过程中，恐惧显然是导致系统变化的原因。
Experiments were performed to determine if movement had been responsible for observed changes in acoustically evoked potentials in the rat during conditioning. In one, peripheral auditory mechanisms operative during movement were bypassed by using electrical stimulation of cochlear nucleus or cochlea to evoke auditory potentials as a conditioned emotional response was established with a photic conditional stimulus (CS). In another, differences in movement during control and photic CS conditions were eliminated by behavioral techniques and by sampling click-evoked potentials in periods of no movement. In both situations, amplitudes of late components of potentials recorded from auditory cortex, medial geniculate body and inferior collieulus were directly related to strength of the conditioned emotional response. Early components of these responses and responses of ventral cochlear nucleus did not show this relationship. Unconditioned fear was also accompanied by increases in amplitudes of evoked potentials. Fear was apparently responsible for the systematic changes during aversive conditioning.