Induction of electroneutral exchanges of H+ with K+ in rat liver mitochondria
Induction of electroneutral exchanges of H+ with K+ in rat liver mitochondria
复制标题
大鼠肝线粒体中 H 与 K 电中性交换的诱导
DOI：
10.1016/0014-5793(78)81078-3
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发表时间：
1978
期刊：
影响因子：
3.5
通讯作者：
L. Pregnolato
中科院分区：
文献类型：
--
作者：
G. Azzone;F. Bortolotto;A. Zanotti;L. Pregnolato
The view of ApH-driven native H’-K’carriers catalyzing an electroneutral H’/K’exchange in native mitochondria meets a crucial dilemma. On one side, the active and rapid matrix shrinkage of mitochondria swollen in a K’medium necessarily involves the occurrence of an electroneutral H’/K’exchange in order to account for a K’flux opposite in polarity to that driven by the membrane potential. On the other side if native mitochondria would possess such a fastoperating H’/K’antiporter the K’distribution in state 4 mitochondria would never approach quasithermodynamic equilibrium. Hence the respiratory rate of valinomycin-treated mitochondria in low K’media would not decline to low levels, as usually observed, and it would not be possible to calculate A $ by applying the Nernst equation to the K’distribution [1 91. The present study suggests one way to overcome this dilemma by showing that a H’/K’exchange activity is induced in rat liver mitochondria following the addition of agents or the establishment of conditions usually thought to result only in an increased K’permeability[lo-l 21. In these cases however it appears that the induction of the H+/K’exchange activity parallels also an increase of H’permeability presumably due to some rearrangement of the membrane structure [131. The view is therefore considered that these induced H’/K’electroneutral fluxes involve a short-range coupling of electrical H’and K+ fluxes and may play a major role in regulating the matrix volume.
通过线粒体进行阳离子运输。
影响因子：
3
作者：
Gunter,TE
通讯作者：
Gunter,TE