Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats.
Fufang Xue Shuan Tong capsules inhibit renal oxidative stress markers and indices of nephropathy in diabetic rats.
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复方血栓通胶囊抑制糖尿病大鼠肾脏氧化应激标志物及肾病指标
DOI：
10.3892/etm.2012.680
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发表时间：
2012-11
影响因子：
2.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Fang D;Wan X;Deng W;Guan H;Ke W;Xiao H;Li Y
复方血栓通胶囊是治疗糖尿病肾病的传统中药。FXST已被证明可以减轻糖尿病大鼠视网膜中升高的氧化应激水平。然而，FXST是否通过相同的机制保护肾脏仍不清楚。在这项研究中，糖尿病是通过高脂肪饮食和低剂量链脲佐菌素诱导大鼠。大鼠经口给予低（450 mg/kg/天）、中（900 mg/kg/天）或高（1800 mg/kg/天）剂量的FXST，持续3个月。另一组在同一时期经口给予50 mg/kg/天。结果表明，所有剂量的FXST减少尿蛋白排泄和肌酐清除率，并改善糖尿病肾病相关的系膜基质扩张。然而，只有中，高剂量的FXST防止肾小球肥大在糖尿病大鼠，高剂量显示出最大的抑制作用与肾小球系膜基质扩张。此外，超氧化物歧化酶活性显着升高，而丙二醛水平显着降低，在肾皮质FXST治疗后。FXST的肾脏保护作用并不劣于用于治疗糖尿病肾病的最常用药物之一的卡托普利。结论：FXST可延缓糖尿病肾病的进展，其中以大剂量FXST对糖尿病肾病病理改变的对抗作用最为显著。FXST的肾脏保护作用是通过减少糖尿病肾病中的氧化应激来诱导的。
Fufang Xue Shuan Tong (FXST) capsules, a traditional Chinese medicine, have been used to treat diabetic nephropathy for many years. FXST has been shown to attenuate elevated levels of oxidative stress in the retina of diabetic rats. However, whether FXST protects kidneys through the same mechanism(s) remains unclear. In this study, diabetes was induced in rats by administration of a high-fat diet and low-dose streptozotocin. Rats were administered low (450 mg/kg/day), middle (900 mg/kg/day) or high (1800 mg/kg/day) doses of FXST orally for 3 months. Another group was administered 50 mg/kg/day orally for the same period. The results indicated that all doses of FXST reduced urinary protein excretion and creatinine clearance and ameliorated the diabetic nephropathy-related mesangial matrix expansion. However, only middle and high doses of FXST prevented glomerular hypertrophy in diabetic rats, and the high dose showed the greatest inhibitory effect with regard to mesangial matrix expansion. Furthermore, superoxide dismutase activities were significantly elevated, whereas malondialdehyde levels were significantly reduced in the renal cortex following FXST treatment. The kidney-protective role of FXST is not inferior to that of captopril, one of the most commonly used drugs for the treatment of diabetic nephropathy. In conclusion, FXST retards the progression of diabetic nephropathy, while high-dose FXST shows the most prominent effect in counteracting the pathological changes of diabetic nephropathy. The renoprotective action of FXST is induced by the reduction of oxidative stress in diabetic nephropathy.
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影响因子：
7.7
作者：
Okada, S;Shikata, K;Makino, H
通讯作者：
Makino, H
影响因子：
5.1
作者：
PAOLETTI, F;MOCALI, A;ALDINUCCI, D
通讯作者：
ALDINUCCI, D
影响因子：
8.2
作者：
De Mattia, G;Bravi, MC;Ferri, C
通讯作者：
Ferri, C
影响因子：
5.1
作者：
Nam, Soo Min;Lee, Mi Young;Chung, Choon Hee
通讯作者：
Chung, Choon Hee
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association