Theories of the pathogenesis of inclusion body myositis.
Theories of the pathogenesis of inclusion body myositis.
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DOI：
10.1007/s11926-010-0102-5
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发表时间：
2010-06
影响因子：
5
通讯作者：
Greenberg, Steven A
中科院分区：
文献类型：
--
作者：
Greenberg, Steven A
包涵体肌炎是一种进行性骨骼肌疾病。在这里，其发病机制的具体理论进行审查和一般考虑有关建模这种疾病的讨论。对包涵体肌炎发病机制的认识仍然极为贫乏。目前已发表的动物模型不能代表该疾病。未来的研究需要考虑生物标志物的关键作用和方法学问题。
Inclusion body myositis is a progressive disease of the skeletal muscle. Here, specific theories of its pathogenesis are reviewed and general considerations pertaining to modeling of this disease discussed. Understanding of inclusion body myositis disease mechanism remains extremely poor. Current published animal models do not represent the disease. Future studies need to consider the critical role of biomarkers and methodologic issues in their discovery.