High-sensitivity optical biosensor based on cascaded Mach-Zehnder interferometer and ring resonator using Vernier effect
High-sensitivity optical biosensor based on cascaded Mach-Zehnder interferometer and ring resonator using Vernier effect
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DOI：
10.1364/ol.39.006363
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发表时间：
2014-11-15
期刊：
影响因子：
3.6
通讯作者：
He, Jian-Jun
中科院分区：
文献类型：
--
作者：
Jiang, Xianxin;Chen, Yangqing;He, Jian-Jun
提出了一种基于级联马赫-曾德尔干涉仪(MZI)和具有游标效应的环形谐振腔的超高灵敏度硅光子生物传感器的波长解调方法。实验结果表明，MZI传感器和MZI环传感器的灵敏度分别达到2870 nm/RIU和21,500 nm/RIU。通过监测山羊和抗山羊免疫球蛋白G(Ig G)对的相互作用，展示了一种生物传感应用。测量结果表明，1 ng/mlIg使MZI传感器和MZI-RING传感器分别产生0.035 nm和0.5 nm的波长漂移。这种高性能传感器在医疗诊断领域具有广阔的应用前景。(C)2014年美国光学学会
We demonstrate an ultrahigh sensitivity silicon photonic biosensor based on cascaded Mach-Zehnder interferometer (MZI) and ring resonator with the Vernier effect using wavelength interrogation. Experimental results show that the sensitivities reached 2870 nm/RIU and 21,500 nm/RIU for MZI sensor and MZI-ring sensor, respectively. A biosensing application was demonstrated by monitoring the interaction between goat and antigoat immunoglobulin G (IgG) pairs. The measured results show that 1 ng/ml IgG resulted in 0.035 nm and 0.5 nm wavelength shift for MZI sensor and MZI-ring sensor, respectively. This high performance sensor is promising for medical diagnostic applications. (C) 2014 Optical Society of America