CYCLIN SYNTHESIS DRIVES THE EARLY EMBRYONIC-CELL CYCLE
CYCLIN SYNTHESIS DRIVES THE EARLY EMBRYONIC-CELL CYCLE
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DOI：
10.1038/339275a0
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发表时间：
1989-05-25
期刊：
影响因子：
64.8
通讯作者：
KIRSCHNER, MW
中科院分区：
文献类型：
--
作者：
MURRAY, AW;KIRSCHNER, MW
我们生产了可以在体外进行多个细胞周期的青蛙卵提取物。内源信使 RNA 的破坏使提取物停滞在间期。添加外源细胞周期蛋白 mRNA 足以产生多个细胞周期。新合成的细胞周期蛋白在每个间期积累，并在每次有丝分裂结束时降解。
We have produced extracts of frog eggs that can perform multiple cell cyclesin vitro. Destruction of the endogenous messenger RNA arrests the extracts in interphase. The addition of exogenous cyclin mRNA is sufficient to produce multiple cell cycles. The newly synthesized cyclin protein accumulates during each interphase and is degraded at the end of each mitosis.