Enhanced Risk of Infection with Device-Associated Thrombi
Enhanced Risk of Infection with Device-Associated Thrombi
复制标题
设备相关血栓感染的风险增加
DOI：
10.1097/00002480-200011000-00039
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发表时间：
2000
期刊：
影响因子：
4.2
通讯作者：
S. Mohammad
中科院分区：
文献类型：
--
作者：
S. Mohammad
血栓形成和感染是接触血液的假体装置的两个众所周知的风险。目前使用的许多生物材料可能为血栓形成以及细菌粘附和定植提供有吸引力的表面。植物性心内膜炎患者的临床经验表明，血栓形成可能导致感染风险增加，并且一些研究人员已经注意到粘附细菌可能增加血栓形成风险的可能性。为了研究血栓形成和感染之间的相关性，进行了一系列测试来评估在不存在和存在血液成分的情况下病原体与表面的亲和力。冠状动脉支架被用作在体外循环回路中吸引血栓的模型装置。使用新鲜肝素化血液来研究血栓形成和细菌相互作用。 111 铟标记的表皮葡萄球菌和 111 铟标记的血小板用于量化各种测试条件下细菌与血栓的相互作用。使用抗凝剂、抗血小板剂和抗生素试图选择性地影响细菌、血小板或血栓形成。结果表明，在适当的条件下，细菌可能会优先粘附在富含血小板的血栓上。这些观察结果还表明，通过降低血栓形成的风险，也可以降低设备相关感染的风险。
Thrombosis and infection are two well-recognized risks with prosthetic devices that contact blood. Many of the currently used biomaterials may present an attractive surface for thrombus development as well as bacterial adhesion and colonization. Clinical experience with vegetative endocarditis patients has suggested that thrombosis may lead to enhanced risk of infection, and the possibility that adherent bacteria may enhance the risk of thrombosis has been noted by several investigators. To investigate the correlation between thrombosis and infection, a series of tests were conducted to assess the affinity of pathogen with surfaces in the absence and presence of blood components. Coronary stents were used as a model device to attract thrombi in a recirculating loop in vitro. Fresh heparinized blood was used to investigate thrombus development and bacterial interaction. 111Indium-labeled Staphylococcus epidermidis and 111Indium-labeled platelets were utilized to quantify bacterial interaction with thrombi under various test conditions. Anticoagulants, antiplatelet agents, and antibiotics were utilized in attempts to selectively influence bacteria, platelets, or thrombosis. The results suggest that under appropriate conditions, bacteria may preferentially adhere to platelet rich thrombus. These observations also suggest that by reducing the risk of thrombosis, the risk of device-associated infection may also be reduced.
影响因子：
6.4
作者：
HERRMANN, M;LAI, QJ;PROCTOR, RA
通讯作者：
PROCTOR, RA