Cohort studies of health effects among people exposed to estuarine waters: North Carolina, Virginia, and Maryland.
Cohort studies of health effects among people exposed to estuarine waters: North Carolina, Virginia, and Maryland.
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DOI：
10.1289/ehp.01109s5781
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发表时间：
2001-10
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
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多种人类症状与暴露于甲藻Pfiesteria有关，并被归类为一种称为“可能的河口相关综合征”的综合征。“与接触可能含有Pfiesteria spp的河口沃茨相关的健康影响的前瞻性队列研究。和相关的生物正在北卡罗来纳州、弗吉尼亚州和马里兰州进行。这三项研究招募了118-238名在河口沃茨工作或从事娱乐活动的受试者。进行基线健康和神经心理学评估，并前瞻性地跟踪研究受试者2-5年，定期评估一系列神经心理学测试的健康和表现。每1-2周通过电话访谈或日记记录健康症状和河口水暴露。水质信息，包括对Pfiesteria spp.的测量，是在实验对象工作的地方收集的。由于不可能测量个体对Pfiesteria或该生物体产生的毒素的暴露，因此这些研究检查了替代暴露措施（例如，在河口沃茨、鱼类捕杀区或通过分子扩增检测到Pfiesteria DNA的沃茨中花费的时间）。对头两年（1998-2000年）数据的初步分析表明，三个正在进行的队列中没有一个发现对健康的不利影响。然而，自研究开始以来，没有任何与Pfiesteria相关的鱼类死亡报告，因此可能没有研究受试者暴露于产毒素Pfiesteria spp。
A variety of human symptoms have been associated with exposure to the dinoflagellate Pfiesteria and have been grouped together into a syndrome termed "possible estuary-associated syndrome." Prospective cohort studies of health effects associated with exposure to estuarine waters that may contain Pfiesteria spp. and related organisms are in progress in North Carolina, Virginia, and Maryland. The three studies recruited cohorts of 118-238 subjects who work or engaged in recreation in estuary waters. Baseline health and neuropsychological evaluations are conducted, and study subjects are followed prospectively for 2-5 years with periodic assessments of health and performance on a battery of neuropsychological tests. Health symptoms and estuary water exposure are recorded by telephone interviews or diaries every 1-2 weeks. Water quality information, including measurements of Pfiesteria spp., is collected in the areas where the subjects are working. Because it is not possible to measure individual exposure to Pfiesteria or a toxin produced by this organism, these studies examine surrogate exposure measures (e.g., time spent in estuary waters, in a fish kill area, or in waters where Pfiesteria DNA was detected by molecular amplification). Preliminary analyses of the first 2 years (1998-2000) of data indicate that none of the three ongoing cohorts have detected adverse health effects. However, there have not been any reported fish kills associated with Pfiesteria since the studies began, so it is possible that none of the study subjects have been exposed to toxin-producing Pfiesteria spp.