Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life
Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life
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DOI：
10.1016/j.neulet.2012.03.091
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发表时间：
2012-05-16
影响因子：
2.5
通讯作者：
Uysal, Nazan
中科院分区：
文献类型：
--
作者：
Aksu, Ilkay;Baykara, Basak;Uysal, Nazan
在之前的一项研究中，我们证明了孕期有规律的有氧运动可以减少母体剥夺引起的焦虑。本研究的目的是探讨母体运动是否对男性和女性子代的生命早期和晚期产生积极影响。每组受试者中，一半在出生26天时接受评估，另一半在4个月大时进行评估。母亲锻炼组的焦虑水平无论是在性别上还是在青春期前和成年期都低于对照组。女性的运动活动增加较多。与对照组相比，母亲锻炼组的前额叶血管内皮生长因子和脑源性神经营养因子的水平在年龄组和性别上都较高。此外，前额叶脑源性神经营养因子水平与旷场试验结果、血管内皮生长因子水平与高架迷宫试验结果呈显著正相关。两组间血清皮质酮水平无差异。这些结果表明，孕期母体锻炼可以保护幼崽在生命的早期和后期免受焦虑的影响，并对前额叶皮质产生积极的影响。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
In a previous study we demonstrated that, regular aerobic exercise during pregnancy decreased maternal deprivation induced anxiety. The purpose of this study is to investigate whether the positive effects of maternal exercise on the male and female offspring's early and late period of life. Half of the test subjects in each group were evaluated when they were 26 days old, and the other half were evaluated when they were 4 months old. The anxiety levels of maternally exercised groups were less than the control groups in both sexes and in both prepubertal and adult periods. The locomotor activity more increased in females. The prefrontal VEGF and BDNF levels were greater for both age groups and sexes in the maternally exercised group compared to control group. Moreover, there was a strong positive correlations between prefrontal cortex BDNF levels and results of open field tests: and VEGF levels and results of elevated plus maze tests. There was no difference in serum corticosterone levels between groups. These results indicate that maternal exercise during pregnancy may protect the pups from anxiety in early and late periods of life, and affects the prefrontal cortex positively. (c) 2012 Elsevier Ireland Ltd. All rights reserved.