MicroRNA regulation of neural stem cells and neurogenesis.
MicroRNA regulation of neural stem cells and neurogenesis.
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DOI：
10.1523/jneurosci.4280-10.2010
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发表时间：
2010-11-10
期刊：
影响因子：
--
通讯作者：
Kosik KS
中科院分区：
文献类型：
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作者：
Shi Y;Zhao X;Hsieh J;Wichterle H;Impey S;Banerjee S;Neveu P;Kosik KS
microrna是一类小RNA调节因子，参与许多细胞过程，包括发育、增殖、分化和可塑性。新兴的概念是，microrna通过调节干细胞调节因子的表达，在控制干细胞自我更新和命运决定之间的平衡中发挥核心作用。本文将重点介绍microrna调控神经干细胞自我更新和神经发生的最新进展。它将涵盖microRNA在整个神经发生过程中的功能，从神经干细胞自我更新和命运决定到神经元成熟，突触形成和可塑性。将讨论microrna与细胞内禀和外源性干细胞参与者（包括转录因子、表观遗传调节因子和外源性信号分子）之间的相互作用。这是在SFN 2010上关于神经干细胞和神经发生的microRNA调控的小型研讨会上所涵盖的主题的总结，并不意味着对该主题的全面回顾。
MicroRNAs are a class of small RNA regulators that are involved in numerous cellular processes, including development, proliferation, differentiation, and plasticity. The emerging concept is that microRNAs play a central role in controlling the balance between stem cell self-renewal and fate-determination by regulating the expression of stem cell regulators. This review will highlight recent advances in the regulation of neural stem cell self-renewal and neurogenesis by microRNAs. It will cover microRNA functions during the entire process of neurogenesis, from neural stem cell self-renewal and fate-determination to neuronal maturation, synaptic formation, and plasticity. The interplay between microRNAs and both cell-intrinsic and extrinsic stem cell players, including transcription factors, epigenetic regulators, and extrinsic signaling molecules will be discussed. This is a summary of the topics covered in the mini-symposium on microRNA regulation of neural stem cells and neurogenesis in SFN 2010 and is not meant to be a comprehensive review of the subject.