Plasma brain natriuretic peptide is a marker of prognostic functional outcome in non-cardioembolic infarction.
Plasma brain natriuretic peptide is a marker of prognostic functional outcome in non-cardioembolic infarction.
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血浆脑钠肽是非心源性梗塞预后功能结果的标志物。
DOI：
10.1016/j.jstrokecerebrovasdis.2015.06.006
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Nakashima K
中科院分区：
文献类型：
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作者：
Kawase S;Kowa H;Suto Y;Fukuda H;Kusumi M;Nakayasu H;Nakashima K
背景非心源性脑梗死（CEI）患者血浆脑钠肽（BNP）水平也较高。我们的目的是评估血浆BNP水平，临床参数和功能结果之间的关系，患者和不CEI.MethodThis研究分析了连续日本急性缺血性卒中患者。研究血浆BNP水平与缺血性脑卒中传统危险因素的相关性。P值小于0.05被认为是statistically significant.ResultsThis研究分析了718例急性缺血性中风患者（445名男性和273名女性，平均年龄73.9岁）。CEI组的平均血浆BNP水平（366.6 pg/ml）显著高于非CEI组（105.6 pg/ml;P<0.01）。对于CEI和非CEI，住院和出院时不良结局（改良兰金量表评分≥3）与血浆BNP水平显著高于良好结局（改良兰金量表评分≤2）相关。在多元回归分析中，log-BNP与CEI中的女性性别、吸烟、甘油三酯和肌酐清除率显著相关。在非CEI，对数BNP与收缩/舒张压，甘油三酯，高密度脂蛋白胆固醇，肌酐clearance. ConclusionInregardless的CEI的存在下，血浆BNP提供了一个标志预后功能的结果。我们阐明了CEI和非CEI中血浆BNP相关的特征和差异，我们的结果表明血浆BNP可以提供急性缺血性中风脑损伤和神经体液动力学的有用标志物。
BackgroundHigh plasma levels of brain natriuretic peptide (BNP) may also be observed in patients with non–cardioembolic infarction (CEI). We aimed to evaluate the relation between plasma BNP level, clinical parameters, and functional outcome in patients with and without CEI.MethodThis study analyzed consecutive Japanese patients with acute ischemic stroke. Correlations between plasma BNP level and conventional risk factors for ischemic stroke were examined. Values ofPless than .05 were considered statistically significant.ResultsThis study analyzed 718 acute ischemic stroke patients (445 men and 273 women; mean age, 73.9 years). Mean plasma level of BNP was significantly higher for CEI (366.6 pg/ml) than for non-CEI (105.6 pg/ml;P< .01). Poor outcome (modified Rankin Scale score ≥3) at hospitalization and discharge were associated with significantly higher plasma BNP level than good outcome (modified Rankin Scale score ≤2) for both CEI and non-CEI. On multiple regression analysis, log-BNP was significantly associated with female sex, smoking, triglyceride, and creatinine clearance in CEI. In non-CEI, log-BNP was significantly associated with systolic/diastolic blood pressure, triglyceride, high-density lipoprotein cholesterol, and creatinine clearance.ConclusionIrrespective of the presence of CEI, plasma BNP offers a marker of prognostic functional outcome. We clarified the characteristics and differences associated with plasma BNP in CEI and non-CEI, and our results suggest that plasma BNP can provide a useful marker of brain damage and neurohumoral dynamics in acute ischemic stroke.