Effects of rest-duration, time-of-day and their interaction on periodic leg movements while awake in restless legs syndrome.
Effects of rest-duration, time-of-day and their interaction on periodic leg movements while awake in restless legs syndrome.
复制标题
休息时间、一天中的时间及其相互作用对不宁腿综合征清醒时周期性腿部运动的影响。
DOI：
10.1016/j.sleep.2005.05.010
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Earley,ChristopherJ
中科院分区：
文献类型：
--
作者：
Allen,RichardP;Dean,Terry;Earley,ChristopherJ
BACKGROUND AND PURPOSEThe diagnostic criteria for restless legs syndrome (RLS) indicate that both time-of-day and rest effects induce or aggravate symptoms. Periodic limb movements while awake (PLMW) provide an objective motor sign of RLS that can be measured during an awake suggested immobilization test (SIT). This study uses the SIT at different times of the day and analyzes time-of-day and duration-of-rest effects and their interaction on the PLMW.PATIENTS AND METHODSTwenty-eight RLS patients who were not on medications had SIT tests at 10 pm, 8 am and 4 pm on two consecutive days. PLMW for each 20-min period were analyzed for time-of-day and rest effects and their interaction. PLMW increase from the first to last 20-min SIT period assessed the rest-effects.RESULTSSignificant effects were found for rest, time-of-day and rest–time-of-day interaction. The rest-effect increased most from morning to afternoon while total PLMW increased more from afternoon to night. Males compared to females had significantly more PLMW and a larger rest-effect change with time-of-day.CONCLUSIONSRest and time-of-day effects and their interaction all increase RLS symptoms. PLMW increase with rest may provide a sensitive measure of symptom severity.
