Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization
Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization
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DOI：
10.1038/sj.mn.7800191
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发表时间：
2003-07-01
期刊：
影响因子：
2.4
通讯作者：
Peters, W
中科院分区：
文献类型：
--
作者：
Charo, IF;Peters, W
单核细胞衍生的巨噬细胞对组织的浸润是多种疾病的重要组成部分，包括动脉粥样硬化、肾小球肾炎、脑炎、感染性疾病和几乎所有以慢性炎症为特征的综合征。负责这种定向迁移的分子信号尚不完全清楚，但趋化因子家族的成员，特别是单核细胞趋化蛋白（MCP）（MCP-1至MCP-5）正在成为关键参与者。对MCP有反应的细胞之所以这样做，是因为它们表达趋化因子受体2（CCR 2），即同源受体。这篇综述将总结支持CCR 2在动脉粥样硬化发病机制、细胞内病原体感染和I型适应性免疫应答调节中的关键作用的证据。
Infiltration of tissues by monocyte-derived macrophages is a prominent component of a wide-range of diseases, including atherosclerosis, glomerulonephritis, encephalitis, infectious diseases, and virtually all syndromes characterized by chronic inflammation. The molecular signals responsible for this directed migration are incompletely understood, but members of the chemokine family, especially the monocyte chemoattractant proteins (MCPs) (MCP-1 to MCP-5) are emerging as key players. Cells that respond to the MCPs do so because they express chemokine receptor 2 (CCR2), the cognate receptor. This review will summarize evidence supporting a key role for CCR2 in the pathogenesis of atherosclerosis, infections with intracellular pathogens, and regulation of the type I adaptive immune response.