Exercise for the heart: signaling pathways.
Exercise for the heart: signaling pathways.
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心脏运动：信号通路
DOI：
10.18632/oncotarget.4770
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发表时间：
2015-08-28
期刊：
影响因子：
--
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Tao L;Bei Y;Zhang H;Xiao J;Li X
体育锻炼作为预防心血管疾病的一种有效的功能干预手段，是近年来研究的热点。运动已被证明可以减少心脏危险因素，防止心肌损伤，并增加心脏功能。这改善了生活质量，降低了各种心血管疾病的死亡率和发病率，包括心肌梗死、心脏缺血/再灌注损伤、糖尿病性心肌病、心脏老化和肺动脉高压。细胞对运动的适应可能与内源性和外源性因素有关：1）运动通过心肌细胞的肥大和更新诱导心脏生长，和2）运动诱导内皮祖细胞增殖、迁移和分化成成熟内皮细胞，引起内皮再生和血管生成。与运动相关的细胞适应是由于几种信号通路的激活，特别是生长因子神经调节蛋白1（NRG 1）-ErbB 4-C/EBPβ和胰岛素样生长因子（IGF）-1-PI 3 k-Akt信号通路。有趣的是，microRNAs（miRNAs，miRs）如miR-222也在运动的有益作用中发挥重要作用。因此，探索运动益处的调节机制将有助于设计新的有效治疗心血管疾病的方法。
Physical exercise, a potent functional intervention in protecting against cardiovascular diseases, is a hot topic in recent years. Exercise has been shown to reduce cardiac risk factors, protect against myocardial damage, and increase cardiac function. This improves quality of life and decreases mortality and morbidity in a variety of cardiovascular diseases, including myocardial infarction, cardiac ischemia/reperfusion injury, diabetic cardiomyopathy, cardiac aging, and pulmonary hypertension. The cellular adaptation to exercise can be associated with both endogenous and exogenous factors: 1) exercise induces cardiac growth via hypertrophy and renewal of cardiomyocytes, and 2) exercise induces endothelial progenitor cells to proliferate, migrate and differentiate into mature endothelial cells, giving rise to endothelial regeneration and angiogenesis. The cellular adaptations associated with exercise are due to the activation of several signaling pathways, in particular, the growth factor neuregulin1 (NRG1)-ErbB4-C/EBPβ and insulin-like growth factor (IGF)-1-PI3k-Akt signaling pathways. Of interest, microRNAs (miRNAs, miRs) such as miR-222 also play a major role in the beneficial effects of exercise. Thus, exploring the mechanisms mediating exercise-induced benefits will be instrumental for devising new effective therapies against cardiovascular diseases.