Developmental influences on circuits programming susceptibility to obesity.
Developmental influences on circuits programming susceptibility to obesity.
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DOI：
10.1016/j.yfrne.2015.07.002
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发表时间：
2015-10
影响因子：
7.4
通讯作者：
Zeltser LM
中科院分区：
文献类型：
--
作者：
Zeltser LM
Suboptimal maternal nutrition exerts lasting impacts on obesity risk in offspring, but the direction of the effect is determined by the timing of exposure. While maternal undernutrition in early pregnancy is associated with increased body mass index, in later pregnancy it can be protective. The importance of the timing of maternal undernutrition is also observed in rodents, however, many of the processes that occur in the last trimester of human gestation are delayed to the postnatal period. Neonatal leptin administration exerts lasting impacts on susceptibility to obesity in rodents. Although leptin can influence the formation of hypothalamic circuits involved in homeostatic control of feeding during the postnatal period, these effects are too late to account for its ability to reverse adverse metabolic programming due to early gestational exposure to maternal undernutrition. This review presents an alternative framework for understanding the effects of neonatal leptin through influences on developing thermoregulatory circuits.
