Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways.
Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways.
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DOI：
10.1038/nchembio.1834
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发表时间：
2015-07
影响因子：
14.8
通讯作者：
Banerjee R
中科院分区：
文献类型：
--
作者：
Mishanina TV;Libiad M;Banerjee R
尽管 H2S 分子能引起深远且多效的生理效应，但参与 H2S 信号传导的化学物质仍然难以捉摸。硫化物信号传导的主要候选机制是靶蛋白的过硫化。然而，H2S 对氧化硫醇（例如二硫化物）的反应性相对较差，电池还原环境中二硫化物浓度较低，以及 H2S 稳态浓度较低，引发了关于氧化硫醇与硫阴离子或还原硫醇与氧化二硫化氢之间反应形成过硫化物的合理性的问题。相比之下，硫化物氧化途径被认为是处理过量硫化物的主要机制，会产生一系列活性硫物质，包括过硫化物、多硫化物和硫代硫酸盐，它们可以修饰目标蛋白质。我们假设硫化物氧化途径介导硫化物信号传导，并且硫转移酶确保目标特异性。
The chemical species involved in H2S signaling remain elusive despite the profound and pleiotropic physiological effects elicited by this molecule. The dominant candidate mechanism for sulfide signaling is persulfidation of target proteins. However, the relatively poor reactivity of H2S toward oxidized thiols, such as disulfides, the low concentration of disulfides in the reducing milieu of the cell and the low steady-state concentration of H2S raise questions about the plausibility of persulfide formation via reaction between an oxidized thiol and a sulfide anion or a reduced thiol and oxidized hydrogen disulfide. In contrast, sulfide oxidation pathways, considered to be primarily mechanisms for disposing of excess sulfide, generate a series of reactive sulfur species, including persulfides, polysulfides and thiosulfate, that could modify target proteins. We posit that sulfide oxidation pathways mediate sulfide signaling and that sulfurtransferases ensure target specificity.