Autoimmune hepatitis following influenza virus vaccination: Two case reports.
Autoimmune hepatitis following influenza virus vaccination: Two case reports.
复制标题
DOI：
10.1097/md.0000000000011621
复制
发表时间：
2018-07
期刊：
影响因子：
1.6
通讯作者：
Takikawa Y
中科院分区：
文献类型：
--
作者：
Sasaki T;Suzuki Y;Ishida K;Kakisaka K;Abe H;Sugai T;Takikawa Y
虽然免疫接种可能会导致自身免疫性肝炎（AIH），但迄今为止，还没有继发于流感病毒疫苗接种的AIH病例报告。本文描述了2名妇女谁开发AIH后接受流感病毒疫苗接种。两名妇女在接受流感病毒疫苗接种后出现肝酶升高。两名患者均被诊断为AIH使用国际自身免疫性肝炎组标准。2例患者均接受泼尼松龙治疗。开始使用泼尼松龙后，观察到两例患者的血清转氨酶水平均恢复至参考范围。接种流感病毒疫苗可能引发AIH的发展。临床医生应该注意的事实是，AIH可以发生在流感病毒疫苗接种后。
Although immunization could possibly cause autoimmune hepatitis (AIH), to date, no cases of AIH have been reported secondary to influenza virus vaccination. This paper describes 2 women who developed AIH after receiving influenza virus vaccination. Two women presented with elevation of liver enzymes after receiving influenza virus vaccination. Both patients were diagnosed with AIH using the International Autoimmune Hepatitis Group criteria. Both patients were treated with prednisolone. After the initiation of prednisolone, serum aminotransferase levels were observed to return to the reference range in both patients. Influenza virus vaccination could trigger the development of AIH. Clinicians should be mindful of the fact that AIH can occur after influenza virus vaccination.