Depressive symptoms in adolescents: associations with white matter volume and marijuana use
Depressive symptoms in adolescents: associations with white matter volume and marijuana use
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DOI：
10.1111/j.1469-7610.2007.01728.x
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发表时间：
2007-06-01
影响因子：
7.6
通讯作者：
Tapert, Susan F.
中科院分区：
文献类型：
--
作者：
Medina, Krista Lisdahl;Nagel, Bonnie J.;Tapert, Susan F.
背景：抑郁情绪与白质减少和海马体积减少有关。然而，在大量吸食大麻的青少年中，大脑结构和情绪之间的关系可能是独一无二的。这项研究的目的是检查青少年大麻使用者和对照组中白质和海马体积与抑郁症状之间的关系。方法：数据来自16-18岁的大麻使用者（n = 16）和人口统计学相似的对照组（n = 16）。广泛的排除标准包括精神和神经障碍，包括重度抑郁症。在监测禁欲28天后，收集物质使用、情绪和解剖学指标。结果：大麻（MJ）使用者表现出比对照组更多的抑郁症状（p < 0.05）。使用MJ （β = 0.42, p < 0.005）和较小的白质体积（β = - 0.34, p < 0.03）在汉密尔顿抑郁评定量表上都预示着更高水平的抑郁症状。MJ使用与白质体积相互作用（β = - 0.55, p < .03）预测贝克抑郁量表的抑郁评分：在MJ使用者中，白质体积与抑郁症状呈负相关，而不是对照组。结论：大麻使用和脑白质体积在预测青少年抑郁症状方面具有叠加性和交互性。细微的神经发育白质异常可能会破坏与情绪调节有关的区域之间的联系。
Background: Depressed mood has been associated with decreased white matter and reduced hippocampal volumes. However, the relationship between brain structure and mood may be unique among adolescents who use marijuana heavily. The goal of this study was to examine the relationship between white matter and hippocampal volumes and depressive symptoms among adolescent marijuana users and controls. Methods: Data were collected from marijuana users (n = 16) and demographically similar controls (n = 16) aged 16-18. Extensive exclusionary criteria included psychiatric and neurologic disorders, including major depression. Substance use, mood, and anatomical measures were collected after 28 days of monitored abstinence. Results: Marijuana (MJ) users demonstrated more depressive symptoms than controls (p < .05). MJ use (beta = .42, p < .005) and smaller white matter volume (beta = -.34, p < .03) each predicted higher levels of depressive symptoms on the Hamilton Depression Rating Scale. MJ use interacted with white matter volume (beta = -.55, p < .03) in predicting depression scores on the Beck Depression Inventory: among MJ users, but not controls, white matter volume was negatively associated with depressive symptoms. Conclusions: Marijuana use and white matter volume were additive and interactive in predicting depressive symptoms among adolescents. Subtle neurodevelopmental white matter abnormalities may disrupt the connections between areas involved in mood regulation.