A new paradigm for biohydroxylation by Beauveria bassiana ATCC 7159
A new paradigm for biohydroxylation by Beauveria bassiana ATCC 7159
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DOI：
10.1016/s0040-4020(99)00393-2
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发表时间：
1999-06-11
期刊：
影响因子：
2.1
通讯作者：
Zabic, M
中科院分区：
文献类型：
--
作者：
Holland, HL;Morris, TA;Zabic, M
研究了球孢白僵菌ATCC 7159对一系列酰胺类及相关氨基、酮和烃类底物的生物羟基化作用。产物分布，以及从使用细胞色素P-450抑制剂异黄樟素、1-氨基苯并三唑和苯乙炔的选择性抑制实验获得的数据，表明B。bassiana含有一系列具有不同底物特异性的羟化酶。一个范例的微生物羟基化的结果的解释和应用现有的活性位点模型B。巴西纳。(C)1999 Elsevier Science Ltd.保留所有权利。
The biohydroxylation of a series of amides and related amino, keto and hydrocarbon substrates by the fungal biocatalyst Beauveria bassiana ATCC 7159 has been examined. The product distributions, together with data obtained from selective inhibition experiments using the cyt.P-450 inhibitors isosafrole, 1-aminobenzotriazole and phenylacetylene, suggest that B. bassiana contains a range of hydroxylase enzymes with different substrate specificities. A paradigm is presented for the interpretation of the results of microbial hydroxylation and for the application of existing active site models for B. bassiana. (C) 1999 Elsevier Science Ltd. All rights reserved.