Correlation between coefficient of variation of choice reaction time and components of event-related potentials (P300): effect of benzodiazepine
Correlation between coefficient of variation of choice reaction time and components of event-related potentials (P300): effect of benzodiazepine
复制标题
DOI：
10.1016/s0022-510x(00)00362-2
复制
发表时间：
2000-09-01
影响因子：
4.4
通讯作者：
Hayashi, R
中科院分区：
文献类型：
--
作者：
Hayashi, R
我们研究了21名健康青年的认知过程准确度与事件相关电位（P300）组成的关系。使用苯二氮卓类药物来控制受试者的认知状态。记录口服0.4 mg阿普唑仑前后P300、选择反应时间（CRT）和错误率（ER）的连续变化。给药后，9例（ⅰ组）患者CRT变异系数有下降趋势，12例（ⅱ组）患者CRT变异系数有上升趋势。治疗后，所有受试者的P300潜伏期均延长；然而，这种变化在II组比I组更明显。在I组，给药前后P300振幅无误差，无显著差异。在II组，阿普唑仑显著降低P300振幅和增加ER。我们的研究结果表明，当中枢神经系统设法减少CRT的波动时，准确性和P300振幅得以保留，但随着这些过程的恶化，P300振幅降低，错误率增加。(C) 2000 Elsevier Science B.V.版权所有
We studied the relationship between accuracy in the cognitive process and components of event-related potentials (P300) in 21 young and healthy subjects. Benzodiazepine was used to manipulate the cognitive state of the subjects. We recorded the serial changes in P300, choice reaction time (CRT), and error ratio (ER) before and after oral administration of 0.4 mg of alprazolam. After administration, the coefficient of variation of CRT tended to decrease in nine subjects (group I) and increase in 12 subjects (group II). Prolongation of the P300 latency was observed in all subjects after treatment; however, such change was more predominant in group II than in group I. In group I, there was no error and no significant difference in P300 amplitude before and after administration. In group II, alprazolam significantly reduced P300 amplitude and increased ER. Our results suggest that the accuracy and P300 amplitude were preserved when the central nerve system managed to reduce fluctuations in CRT but P300 amplitude diminished and the error ratio increased following deterioration of these processes. (C) 2000 Elsevier Science B.V. All rights reserved.