THE CLINICAL AND PATHOLOGICAL SPECTRUM OF STEELE-RICHARDSON-OLSZEWSKI SYNDROME (PROGRESSIVE SUPRANUCLEAR PALSY) - A REAPPRAISAL
THE CLINICAL AND PATHOLOGICAL SPECTRUM OF STEELE-RICHARDSON-OLSZEWSKI SYNDROME (PROGRESSIVE SUPRANUCLEAR PALSY) - A REAPPRAISAL
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DOI：
10.1093/brain/118.3.759
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发表时间：
1995-06-01
期刊：
影响因子：
14.5
通讯作者：
LEES, AJ
中科院分区：
文献类型：
--
作者：
DANIEL, SE;DEBRUIN, VMS;LEES, AJ
研究人员对 17 名患有进行性运动迟缓综合征的患者进行了研究，死后发现大脑皮层、皮层下核团和脑干神经原纤维变性。 7 例符合目前公认的 Steele-Richardson-Olszewski 综合征临床诊断标准，而其余缺乏核上性凝视麻痹的患者有其他临床诊断（特发性帕金森病，6 例；脑血管疾病，2 例；帕金森综合征，1 例；阿尔茨海默病，1 例）。比较两组的临床和病理结果，试图更好地定义 Steele-Richardson-Olszewski 病的谱系。
Seventeen patients with a progressive bradykinetic syndrome and post-mortem findings of neurofibrillary degeneration in cerebral cortex, subcortical nuclei and brainstem were studied. Seven fulfilled currently accepted clinical diagnostic criteria for Steele-Richardson-Olszewski syndrome, whereas the remainder who lacked supranuclear gaze palsy had alternative clinical diagnoses (idiopathic Parkinson's disease, six cases; cerebrovascular disease, two cases; Parkinson's syndrome, one case; Alzheimer's disease, one case). The clinical and pathological findings of the two groups were compared in an attempt to better define the spectrum of Steele-Richardson-Olszewski disease.