Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats
Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats
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DOI：
10.1002/ptr.2034
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发表时间：
2007-02-01
影响因子：
7.2
通讯作者：
Fujiwara, Michihiro
中科院分区：
文献类型：
--
作者：
Egashira, Nobuaki;Manome, Naomi;Fujiwara, Michihiro
本研究采用八臂放射状迷宫实验研究了汉方药神药丸（KKT）对大鼠空间记忆障碍的影响。东莨菪碱（0.5 mg/kg，i. p.），非选择性毒蕈碱受体拮抗剂和A-四氢大麻酚（THC; 6 mg/kg，i. p.），大麻的主要精神活性成分，每一种都明显损害了空间记忆。KKT（1和3 mg/kg，p.o.）显著改善东莨菪碱引起的空间记忆障碍。KKT（30 mg/kg，p.o.）还显著改善THC诱导的空间记忆障碍。此外，KKT（3和30 mg/kg，p.o.）增强由毒蕈碱M 1受体激动剂氧震颤素诱导的震颤。总之，这些发现表明KKT是一种治疗记忆缺陷的有用药物。版权所有（c）2006约翰威利父子有限公司。
The present study investigated the effects of Kamikihi-to (KKT), a Kampo medicine, on impairment of spatial memory in rats using an eight-arm radial maze task. Scopolamine (0.5 mg/kg, i.p.), a non-selective muscarinic receptor antagonist, and A-tetrahydrocannabinol (THC; 6 mg/kg, i.p.), a principal psychoactive component of marihuana, each markedly impaired the spatial memory. KKT (1 and 3 mg/kg, p.o.) significantly improved the scopolamine-induced impairment of spatial memory. KKT (30 mg/kg, p.o.) also improved significantly the THC-induced impairment of spatial memory. Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M, receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits. Copyright (c) 2006 John Wiley & Sons, Ltd.