Sudden death in young dogs with myocarditis caused by parvovirus.
Sudden death in young dogs with myocarditis caused by parvovirus.
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患有细小病毒引起的心肌炎的幼犬突然死亡。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
Babiuk La
中科院分区：
文献类型：
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作者：
Hayes Ma;Russell Rg;Babiuk La
由于严重的、原发的、非化脓性心肌炎，加拿大西部最近发生了4至6周龄幼崽的猝死。尸检时，肉眼可见明显的肺水肿，显微镜下，心肌纤维内可见特征性的核内包涵体，与心肌炎有关。在超微结构上，核内包涵体内可见大量类似细小病毒的小颗粒，犬细小病毒直接荧光抗体试验阳性。在三只接种了病态心肌匀浆的幼崽中，一只出现了类似犬细小病毒性肠炎的病变。
Sudden death of pups in the 4- to 6-week age range has recently been occurring in western Canada as a result of severe, primary, nonsuppurative myocarditis. At necropsy, the prominent macroscopic lesion was pulmonary edema, and microscopically, characteristic intranuclear inclusion bodies were found within cardiac myofibers in association with myocarditis. Ultrastructurally, numerous small particles resembling parvoviruses were found within the intranuclear inclusion bodies, which were positive by direct fluorescent antibody test for canine parvovirus. Of three pups inoculated with homogenate from affected myocardium, one developed lesions resembling canine parvoviral enteritis.