FLEXIBLE REGRESSION-MODELS WITH CUBIC-SPLINES

FLEXIBLE REGRESSION-MODELS WITH CUBIC-SPLINES
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DOI:
10.1002/sim.4780080504
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发表时间:
1989-05-01
影响因子:
2
通讯作者:
SIMON, R
SIMON, R
中科院分区:
医学3区
文献类型:
--
作者:
DURRLEMAN, S;SIMON, R

文献摘要

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我们描述了在回归模型中使用三次样条来表示响应变量和协变量向量之间的关系。这种简单的方法可以帮助防止由于不适当的线性假设而导致的问题。我们比较了限制性三次样条回归非参数程序的特点之间的关系,年龄和生存在斯坦福大学心脏移植数据。我们还提供了一个癌症治疗的说明性例子。
We describe the use of cubic splines in regression models to represent the relationship between the response variable and a vector of covariates. This simple method can help prevent the problems that result from inappropriate linearity assumptions. We compare restricted cubic spline regression to non-parametric procedures for characterizing the relationship between age and survival in the Stanford Heart Transplant data. We also provide an illustrative example in cancer therapeutics.