Thermodynamic models for determination of the solid-liquid equilibrium of istradefylline in ethyl acetate plus (isopropanol, tetrahydrofuran, acetone) binary solvent mixtures
Thermodynamic models for determination of the solid-liquid equilibrium of istradefylline in ethyl acetate plus (isopropanol, tetrahydrofuran, acetone) binary solvent mixtures
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DOI：
10.1016/j.jct.2017.03.015
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Fangfang Shen
中科院分区：
文献类型：
--
作者：
Tianhua Huang;Dingqiang Lu;Xiuquan Ling;Xinxian Wang;Tongqi Liu;Fangfang Shen
In this paper, we focused on solubility and solution thermodynamics of istradefylline. Herein, we investigated the solubility and solution thermodynamics of istradefylline in binary solvent mixtures by gravimetric method. The solubility of istradefylline in (ethyl acetate + isopropanol), (ethyl acetate + tetrahydrofuran) and (ethyl acetate + acetone) was measured in the temperature range of 278.15 K– 333.15 K under atmospheric pressure. In order to correlate the solubility of istradefylline, we employed.the modified Apelblat equation, general cosolvency model and Jouyban-Acree model. Computational results showed that the modified Apelblat equation and general cosolvency model have low mean deviation. As calculated by van’t Hoff equation, the values of thermodynamic properties such as Gibbs energy, enthalpy, and entropy proved that the dissolution process is endothermic
