PHENOTYPIC CORRELATIONS BETWEEN OCULOMOTOR FUNCTIONING AND SCHIZOPHRENIA-RELATED CHARACTERISTICS IN RELATIVES OF SCHIZOPHRENIC PROBANDS
PHENOTYPIC CORRELATIONS BETWEEN OCULOMOTOR FUNCTIONING AND SCHIZOPHRENIA-RELATED CHARACTERISTICS IN RELATIVES OF SCHIZOPHRENIC PROBANDS
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DOI：
10.1111/j.1469-8986.1991.tb01995.x
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发表时间：
1991-09-01
期刊：
影响因子：
3.7
通讯作者：
HAAS, G
中科院分区：
文献类型：
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作者：
CLEMENTZ, BA;SWEENEY, JA;HAAS, G
精神分裂症先证者的一级亲属视觉追踪异常是常见的。然而，这些家庭成员的眼球运动异常与精神分裂症相关特征之间的关系却很少受到关注。对24例精神分裂症先证者的53名一级亲属采用面谈(精神分裂人格问卷)和问卷(查普曼量表)对精神分裂症相关特征进行评估。这些家庭成员还在追踪任务中记录了他们的眼球运动，并在频率和时间域上进行了得分，以及扫视干扰。社交-人际精神分裂症相关特征与时间域和频域增益计算均显著相关。看来，追求平滑的眼球运动系统的异常可能与推测与精神分裂症的遗传素质最密切相关的症状有关。这些发现提供了进一步的证据，表明眼球运动异常可能与这种疾病的风险有关。
Abnormalities of visual pursuit tracking are frequent in the first-degree relatives of probands with schizophrenia. The relationship between oculomotor abnormalities and schizophrenia-related characteristics in those family members, however, has received little attention. Fifty-three first-degree relatives of 24 probands with schizophrenia were evaluated for the presence of schizophrenia-related characteristics using both interview (Schedule for Schizotypal Personalities) and questionnaire (Chapman scales). The family members also had their eye movements recorded during pursuit tracking tasks and scored for gain in both the frequency and time domains, and saccadic intrusions. Social-interpersonal schizophrenia-related features were significantly related to both time- and frequency-domain gain calculations. It appears that abnormalities in the smooth-pursuit oculomotor system may be associated with symptoms conjectured to be most closely related to a genetic diathesis for schizophrenia. These findings provide further evidence that oculomotor abnormalities may be related to risk for this disorder.