Regional and directional variations in the mechanical properties of ascending thoracic aortic aneurysms
Regional and directional variations in the mechanical properties of ascending thoracic aortic aneurysms
复制标题
DOI：
10.1016/j.medengphy.2008.03.002
复制
发表时间：
2009-01-01
影响因子：
2.2
通讯作者：
Sokolis, Dimitrios P.
中科院分区：
文献类型：
--
作者：
Iliopoulos, Dimitrios C.;Deveja, Rejar P.;Sokolis, Dimitrios P.
本研究旨在评估胸升主动脉瘤（ATAA）力学特性的区域和方向差异。从12名接受择期手术修复的患者中取出完整的新鲜ATAA，并切成组织标本。根据方向和区域将其分组，并进行单轴断裂试验。在大多数试验中，主动脉壁的内层首先破裂;在所有区域中，周向失效应力（组织强度的测量）和峰值弹性模量（组织刚度的测量）均显著较高。ATAA的力学性能存在明显的异质性，纵向上前部区域是所有区域中最弱和最不僵硬的。未发现失效应力与ATAA直径或患者年龄之间存在相关性。破坏应力与壁厚呈负相关，与峰值弹性模量呈正相关。目前的信息，有关区域和方向的差异，可以提供一个更好的理解的机制，负责发展的环周撕裂的内主动脉壁层在ATAA夹层。(C)2008年妇女平等问题国际研究所。由爱思唯尔有限公司出版。保留所有权利。
This study aimed to assess regional and directional differences in the mechanical properties of ascending thoracic aortic aneurysms (ATAA). Whole fresh ATAA were taken from twelve patients, undergoing elective surgical repair, and cut into tissue specimens. These were divided into groups according to direction and region, and subjected to uniaxial testing beyond rupture. In the majority of tests, the inner layers of the aortic wall ruptured first; failure stress (measure of tissue strength) and peak elastic modulus (measure of tissue stiffness) were significantly higher circumferentially in all regions. Marked heterogeneity was evident in the mechanical properties of ATAA, with the anterior region longitudinally being the weakest and least stiff of all regions. No correlation was found between failure stress and ATAA diameter or patient age. Failure stress showed inverse correlations with wall thickness and direct correlations with peak elastic modulus. The current information, relating to regional and directional differences, may provide a better understanding of the mechanism responsible for the development of circumferential tears of the inner aortic wall layers in ATAA dissections. (C) 2008 IPEM. Published by Elsevier Ltd. All rights reserved.