New advances in molecular approaches to head and neck squamous cell carcinoma.
New advances in molecular approaches to head and neck squamous cell carcinoma.
复制标题
DOI：
10.1097/cad.0b013e32834249ba
复制
发表时间：
2011-08
影响因子：
2.3
通讯作者：
Grandis JR
中科院分区：
文献类型：
--
作者：
Sahu N;Grandis JR
头颈部鳞状细胞癌（HNSCC）是世界上第六大常见癌症。尽管在综合治疗方面取得了进展，但仍观察到局部复发、转移和第二原发肿瘤发展的不良结局。由于肿瘤在分子和遗传病因学上各不相同，并且由于在组织病理学正常的组织中通常已经存在分子水平的失调，因此仅使用临床和病理学标准进行风险分层已被证明是不够的。在这篇文章中，读者将获得通过先进的技术和数据解释在微阵列分析和蛋白质组学的生物标志物发现的当前进展的赞赏。此外，其他分子靶点，除了表皮生长因子受体，讨论了他们在预测复发，治疗反应，生存和总体预后的前景。
Head and neck squamous cell cancer (HNSCC) is the sixth most common cancer in the world. Despite advances in combined modality therapy, poor outcomes continue to be observed in the form of locoregional recurrence, metastasis, and development of second primary tumors. Because tumors vary in their molecular and genetic etiology and because often times there is already deregulation at the molecular level in otherwise histopathologically normal tissue, risk stratification using clinical and pathologic criteria alone has proved to be inadequate. In this article, the reader will gain an appreciation for the current advances in biomarker discovery via advanced technology and data interpretation in microarray analysis and proteomics. In addition, other molecular targets, aside from EGFR, are discussed in the context of their promising role in predicting recurrence, response to therapy, survival and overall prognosis.