Crossed Cerebellar Diaschisis in Alzheimer's Disease Detected by Arterial Spin-labelling Perfusion MRI
Crossed Cerebellar Diaschisis in Alzheimer's Disease Detected by Arterial Spin-labelling Perfusion MRI
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DOI：
10.21873/invivo.12366
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发表时间：
2021-03-01
期刊：
影响因子：
2.3
通讯作者：
Foerster, Alex
中科院分区：
文献类型：
--
作者：
Hertel, Alexander;Wenz, Holger;Foerster, Alex
背景：交叉性小脑神经联系不能（CCD）是一种小脑代谢低下、灌注不足的现象。使用动脉自旋标记灌注加权磁共振成像（ASL PWI），我们调查了CCD在阿尔茨海默病（AD）患者中的频率以及有无CCD患者之间的差异。患者和方法：在接受标准化磁共振成像（包括ASL PWI）的AD患者中，评价小脑中的脑血流量，并使用mdbrain（mediaire GmbH，柏林，德国）和FSL FIRST（脑功能磁共振成像软件库）进行脑分割/容积测定。结果：共纳入65例患者，22例（33.8%）患者被评估为CCD阳性。与无CCD的患者相比，CCD患者的全脑体积（862.8 +/- 49.9 vs. 893.7 +/- 62.7 ml，p=0.049）以及白色物质体积（352.9 +/- 28.0 vs. 374.3 +/- 30.7，p=0.008）显著较小。结论：在大约三分之一的AD患者中，通过ASL PWI可以检测到CCD，并且与较小的全脑和白色物质体积相关。
Background: Crossed cerebellar diaschisis (CCD) is a phenomenon with depressed metabolism and hypoperfusion in the cerebellum. Using arterial spin-labelling perfusion weighted magnetic resonance imaging (ASL PWI), we investigated the frequency of CCD in patients with Alzheimer's disease (AD) and differences between patients with and without CCD. Patients and Methods: In patients with AD who underwent a standardized magnetic resonance imaging including ASL PWI cerebral blood flow was evaluated in the cerebellum, and brain segmentation/ volumetry was performed using mdbrain (mediaire GmbH, Berlin, Germany) and FSL FIRST (Functional Magnetic Resonance Imaging of the Brain Software Library). Results: In total, 65 patients were included, and 22 (33.8%) patients were assessed as being CCD-positive. Patients with CCD had a significantly smaller whole brain volume (862.8 +/- 49.9 vs. 893.7 +/- 62.7 ml, p=0.049) as well as white matter volume (352.9 +/- 28.0 vs. 374.3 +/- 30.7, p=0.008) in comparison to patients without CCD. Conclusion: It was possible to detect CCD by ASL PWI in approximately one-third of patients with AD and was associated with smaller whole brain and white matter volume.