In vitro activity of TD-6424 against Staphylococcus aureus
In vitro activity of TD-6424 against Staphylococcus aureus
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DOI：
10.1128/aac.47.11.3602-3604.2003
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发表时间：
2003-11-01
影响因子：
4.9
通讯作者：
Kaniga, K
中科院分区：
文献类型：
--
作者：
Pace, JL;Krause, K;Kaniga, K
TD-6424是一种具有多种作用机制的快速杀菌剂，对甲氧西林敏感和耐甲氧西林金黄色葡萄球菌的体外杀菌效果比现有的药物更强、更快。TD-6424对这些生物产生持续4至6小时的抗生素后效应。结果提示对金黄色葡萄球菌的敏感和耐药菌株具有潜在的疗效。
TD-6424, a rapidly bactericidal agent with multiple mechanisms of action, is more potent in vitro and more rapidly bactericidal than currently available agents against methicillin-susceptible and methicillin-resistant Staphylococcus aureus. TD-6424 produces a postantibiotic effect with a duration of 4 to 6 h against these organisms. The results suggest potential efficacy against susceptible and resistant strains of S. aureus.