A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes.
A Single Bout of Premeal Resistance Exercise Improves Postprandial Glucose Metabolism in Obese Men with Prediabetes.
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DOI：
10.1249/mss.0000000000002538
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发表时间：
2021-04-01
影响因子：
4.1
通讯作者：
Cade WT
中科院分区：
文献类型：
--
作者：
Bittel AJ;Bittel DC;Mittendorfer B;Patterson BW;Okunade AL;Abumrad NA;Reeds DN;Cade WT
糖尿病前期是2型糖尿病和心血管疾病的主要危险因素。虽然建议糖尿病前期患者进行抗阻运动 (RE)，但人们对 RE 对该人群餐后葡萄糖代谢的影响知之甚少。因此，本研究的目的是阐明 RE 如何影响肥胖和糖尿病前期久坐男性的餐后血糖动力学、胰岛素敏感性、β 细胞功能和后续进餐期间的葡萄糖氧化。我们采用随机交叉研究设计，对 10 名患有肥胖症（BMI：33 ± 3 kg/m2）和糖尿病前期的久坐男性进行了研究。经过一整夜的禁食后，参与者要么完成一轮全身 RE（7 次练习，3 组重复 10-12 次，每组重复次数最多为 80%），要么完成同等时间的休息。参与者随后完成混合膳食测试并结合静脉[6,6-2H2]葡萄糖输注，以确定基础和餐后血糖在血浆中的出现率（Ra）和消失率（Rd）、胰岛素敏感性和胰岛素生成指数（β细胞功能的衡量标准）。餐后 90 分钟进行骨骼肌活检，以评估丙酮酸支持的最大线粒体呼吸。使用间接量热法评估全身碳水化合物氧化。 RE显着降低了餐后葡萄糖Ra和血浆葡萄糖浓度的升高。 RE后餐后胰岛素敏感性显着升高，而餐后血浆胰岛素浓度显着降低。 RE 对胰岛素生成指数、餐后丙酮酸呼吸或碳水化合物氧化没有影响。单次 RE 对肥胖和糖尿病前期男性的餐后葡萄糖代谢具有有益影响，可提高餐后胰岛素敏感性、减少餐后血糖 Ra 升高并降低餐后血浆胰岛素浓度。
Prediabetes is a major risk factor for type 2 diabetes and cardiovascular diseases. While resistance exercise (RE) is recommended for individuals with prediabetes, the effects of RE on postprandial glucose metabolism in this population are poorly understood. Therefore, the purpose of this study was to elucidate how RE affects postprandial glucose kinetics, insulin sensitivity, beta cell function, and glucose oxidation during the subsequent meal in sedentary men with obesity and prediabetes. We studied 10 sedentary men with obesity (BMI: 33 ± 3 kg/m2) and prediabetes by using a randomized, cross-over study design. After an overnight fast, participants completed either a single bout of whole-body RE (7 exercises, 3 sets of 10-12 repetitions at 80% 1-repetition maximum each) or an equivalent period of rest. Participants subsequently completed a mixed meal test in conjunction with an intravenous [6,6-2H2]glucose infusion to determine basal and postprandial glucose rate of appearance (Ra) and disappearance (Rd) from plasma, insulin sensitivity, and the insulinogenic index (a measure of beta cell function). Skeletal muscle biopsies were obtained 90 min post-meal to evaluate pyruvate-supported and maximal mitochondrial respiration. Whole-body carbohydrate oxidation was assessed using indirect calorimetry. RE significantly reduced the postprandial rise in glucose Ra and plasma glucose concentration. Postprandial insulin sensitivity was significantly greater after RE, while postprandial plasma insulin concentration was significantly reduced. RE had no effect on the insulinogenic index, postprandial pyruvate respiration, or carbohydrate oxidation. A single bout of RE has beneficial effects on postprandial glucose metabolism in men with obesity and pre-diabetes by increasing postprandial insulin sensitivity, reducing the postprandial rise in glucose Ra, and reducing postprandial plasma insulin concentration.