beta-endorphin response to exercise - An update
beta-endorphin response to exercise - An update
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DOI：
10.2165/00007256-199724010-00002
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发表时间：
1997-07-01
期刊：
影响因子：
9.8
通讯作者：
Jamurtas, AZ
中科院分区：
文献类型：
--
作者：
Goldfarb, AH;Jamurtas, AZ
β-内啡肽是一种由31个氨基酸组成的多肽，主要在脑下垂体前叶合成，并从其较大的前体分子阿片黑素皮质素原中裂解出来。β-内啡肽可以从脑下垂体释放到循环中，也可以通过神经纤维投射到大脑的各个区域。已经证明，足够的强度和持续时间的运动可以增加循环中的β-内啡肽水平。以前的综述介绍了阿片类药物和运动的背景，并讨论了有氧运动和无氧运动时β-内啡肽水平的变化。本文就β-内啡肽对运动的反应作一综述。这篇综述表明，运动诱导的β-内啡肽改变与运动类型和测试的特殊人群有关，并且在有健康问题的个体中可能有所不同。此外，可能导致循环中的β-内啡肽变化的一些可能机制包括止痛、乳酸或碱过量以及代谢因素。根据运动类型的不同，运动过程中调节β-内啡肽释放的机制可能不同。
beta-Endorphin, a 31-amino-acid peptide, is primarily synthesised in the anterior pituitary gland and cleaved from pro-opiomelanocortin, its larger precursor molecule. beta-Endorphin can be released into the circulation from the pituitary gland or can project into areas of the brain through nerve fibres. Exercise of sufficient intensity and duration has been demonstrated to increase circulating beta-endorphin levels. Previous reviews have presented the background of opioids and exercise and discussed the changes in beta-endorphin levels in response to aerobic and anaerobic exercise. The present review is to update the response of beta-endorphin to exercise. This review suggests that exercise-induced beta-endorphin alterations are related to type of exercise and special populations tested, and may differ in individuals with health problems. Additionally, some of the possible mechanisms which may induce beta-endorphin changes in the circulation include analgesia, lactate or base excess, and metabolic factors. Based on the type of exercise, different mechanisms may be involved in the regulation of beta-endorphin release during exercise.