Vascular Endothelial Growth Factor
Vascular Endothelial Growth Factor
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DOI：
10.1161/atvbaha.108.179663
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发表时间：
2009-06-01
影响因子：
8.7
通讯作者：
Ferrara, Napoleone
中科院分区：
文献类型：
--
作者：
Ferrara, Napoleone
血管内皮生长因子（VEGF，VEGF-A）是生理和病理性血管生成的主要调节因子。FDA已批准几种VEGF抑制剂用于治疗晚期癌症和新生血管性年龄相关性黄斑变性。这个简短的审查提供了一个历史性的帐户与VEGF的发现和阐明这种分子在调节血管生成的作用的早期步骤的挑战。（Arterioscler Thromb Vasc Biol.2009;29：789-791.）
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis. (Arterioscler Thromb Vasc Biol. 2009;29:789-791.)