Age and gender are the strongest clinical correlates of prevalent coronary calcification (R1)
Age and gender are the strongest clinical correlates of prevalent coronary calcification (R1)
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DOI：
10.1016/j.ijcard.2004.03.015
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发表时间：
2005-02-15
影响因子：
3.5
通讯作者：
Wright, CM
中科院分区：
文献类型：
--
作者：
Allison, MA;Wright, CM
目的：确定哪些标准心血管危险因素与流行的冠状动脉钙化（CAC）的相关性最强。研究设计和设置：对 6086 名连续受试者进行的横断面研究，这些受试者在加利福尼亚州圣地亚哥的一所私立大学附属疾病预防中心接受了 CAC 电子束计算机断层扫描。结果：男性年龄与冠状动脉钙化评分之间的相关性 (r = 0.463) 是第二高相关性 (0.218) 体脂百分比的两倍。女性也发现了类似的关系（0.413 vs. 0.238）。男性和女性的钙分数按年龄组逐渐增加。低密度脂蛋白胆固醇不存在这种增加模式。与 45 岁以下的男性和女性相比，74 岁以上的男性和女性出现钙化冠状动脉粥样硬化的风险显着升高（OR [95% CI]：分别为 11.08 [6.186-19.859] 和 11.81 [6.718-20.746]）。添加其他传统心血管危险因素并没有显着增加 ROC 分析中年龄所提供的歧视力。结论：除了其他危险因素之外，年龄和性别与冠状动脉钙化具有显着的独立临床相关性。这些结果支持年龄是冠状动脉钙化的主要危险因素的假设。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
Objective: To determine which of the standard cardiovascular risk factors have the strongest associations with prevalent coronary artery calcification (CAC). Study design and setting: A cross-sectional study of 6086 consecutive subjects who underwent electron beam computed tomography for CAC at a private, university-affiliated disease prevention center in San Diego, CA. Results: The correlation between age and coronary calcium score in men (r = 0.463) was twice that of the next highest correlation (0.218) for percent body fat. A similar relationship was found for women (0.413 vs. 0.238). Calcium scores increased incrementally by age category in both men and women. This pattern of increase was not present for LDL cholesterol. Men and women over the age of 74 had highly elevated risks for the presence of any calcified coronary atherosclerosis compared to those under the age of 45 (OR [95% CI]: 11.08 [6.186-19.859] and 11.81 [6.718-20.746], respectively). Addition of the other traditional cardiovascular risk factors did not significantly increase the discriminatory power beyond that provided by age on ROC analysis. Conclusion: Age and gender are significant independent clinical correlates of coronary calcium beyond that provided by the other risk factors. These results support the hypothesis that age is the predominant risk factor for coronary calcification. (C) 2004 Elsevier Ireland Ltd. All rights reserved.