Association of the upregulated expression of focal adhesion kinase with poor prognosis and tumor dissemination in hypopharyngeal cancer.
Association of the upregulated expression of focal adhesion kinase with poor prognosis and tumor dissemination in hypopharyngeal cancer.
复制标题
粘着斑激酶表达上调与下咽癌不良预后和肿瘤扩散的关系。
DOI：
10.1002/hed.24176
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yamasoba T
中科院分区：
文献类型：
--
作者：
Omura G;Ando M;Saito Y;Kobayashi K;Yoshida M;Ebihara Y;Kanaya K;Fujimoto C;Sakamoto T;Kondo K;Asakage T;Yamasoba T
研究背景粘着斑激酶（FAK）在肿瘤转移中发挥重要作用。本研究的目的是评估FAK表达在手术治疗的下咽癌患者中的意义。方法我们回顾性回顾了2004年至2012年在我们机构治疗的患者的临床图表，并确定了87例下咽癌患者。使用免疫组织化学回顾性评估 FAK 表达状态。结果FAK 阳性患者的疾病特异性生存率明显低于 FAK 阴性患者 (p= .001)。多变量分析显示，FAK 阳性和囊外扩散 (ECS) 是独立的、显着的不良预后因素。此外，FAK 阳性与转移淋巴结的数量显着相关 (p= .048)，FAK 阳性患者的远处转移发生率较高 (p= .009)。 结论 目前的研究表明，FAK 表达上调与下咽癌手术治疗患者的不良预后和肿瘤扩散相关。 © 2016 Wiley periodicals, Inc. Head Neck 38:1164–1169, 2016
BackgroundFocal adhesion kinase (FAK) plays an important role in tumor metastasis. The purpose of this study was to evaluate the significance of FAK expression in surgically treated patients with hypopharyngeal cancer.MethodsWe retrospectively reviewed the clinical charts of patients treated at our institution between 2004 and 2012 and identified 87 patients with hypopharyngeal cancer. FAK expression status was retrospectively evaluated using immunohistochemistry.ResultsFAK‐positive patients displayed significantly worse disease‐specific survival than FAK‐negative patients (p= .001). Multivariate analyses revealed that FAK positivity and extracapsular spread (ECS) were independent, significant adverse prognostic factors. Furthermore, FAK positivity significantly correlated with the number of metastatic lymph nodes (p= .048), and FAK‐positive patients displayed a higher incidence of distant metastases (p= .009).ConclusionThe current study demonstrated that upregulated FAK expression correlates with poor prognosis and tumor dissemination in surgically treated patients with hypopharyngeal cancer. © 2016 Wiley Periodicals, Inc. Head Neck 38:1164–1169, 2016