Hidden Complexity of Synaptic Receptive Fields in Cat V1
Hidden Complexity of Synaptic Receptive Fields in Cat V1
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DOI：
10.1523/jneurosci.0474-13.2014
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发表时间：
2014-04-16
影响因子：
5.3
通讯作者：
Fregnac, Yves
中科院分区：
文献类型：
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作者：
Fournier, Julien;Monier, Cyril;Fregnac, Yves
在初级视觉皮层 (V1) 中，简单和复杂感受野 (RF) 通常根据细胞对相反对比度刺激的尖峰响应的线性来表征。这种分类是否反映了简单和复杂细胞突触输入的功能二分法仍然是一个悬而未决的问题。在这里，我们将 cat V1 中的细胞内膜电位记录与 2D 密集噪声刺激相结合，将阈下 RF 的简单类和复杂类成分分解为一组平行的功能不同的亚基。结果表明，即使在第 4 层和第 6 层简单细胞中，简单和复杂 RF 都表现出兴奋性和抑制性复杂贡献的显着多样性，其方向和空间频率选择性与线性 RF 不同。我们进一步表明，在亚阈值水平恢复的类复合物贡献的多样性在细胞尖峰输出中得到表达。这些结果表明，V1 RF 的简单或复杂性质并不依赖于细胞从其突触传入接收到的类复杂成分的多样性，而是依赖于类简单和类复杂突触贡献的权重之间的不平衡。
In the primary visual cortex (V1), Simple and Complex receptive fields (RFs) are usually characterized on the basis of the linearity of the cell spiking response to stimuli of opposite contrast. Whether or not this classification reflects a functional dichotomy in the synaptic inputs to Simple and Complex cells is still an open issue. Here we combined intracellular membrane potential recordings in cat V1 with 2D dense noise stimulation to decompose the Simple-like and Complex-like components of the subthreshold RF into a parallel set of functionally distinct subunits. Results show that both Simple and Complex RFs exhibit a remarkable diversity of excitatory and inhibitory Complex-like contributions, which differ in orientation and spatial frequency selectivity from the linear RF, even in layer 4 and layer 6 Simple cells. We further show that the diversity of Complex-like contributions recovered at the subthreshold level is expressed in the cell spiking output. These results demonstrate that the Simple or Complex nature of V1 RFs does not rely on the diversity of Complex-like components received by the cell from its synaptic afferents but on the imbalance between the weights of the Simple-like and Complex-like synaptic contributions.