MECHANISMS OF ANEMIA IN PROTEIN-ENERGY MALNUTRITION IN JOHANNESBURG
MECHANISMS OF ANEMIA IN PROTEIN-ENERGY MALNUTRITION IN JOHANNESBURG
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DOI：
10.1093/ajcn/35.2.229
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发表时间：
1982-01-01
影响因子：
7.1
通讯作者：
QUIRK, M
中科院分区：
文献类型：
--
作者：
MACDOUGALL, LG;MOODLEY, G;QUIRK, M
Studies of red cell metabolism, erythropoietin concentration, Fe and folate status were made in 48 children with protein-energy malnutrition in Johannesburg (altitude 1800 m). Biochemical evidence of Fe deficiency was presented in 26% cases on admission and developed in 90% during recovery. Biochemical evidence of folate deficiency was present in 14% of cases on admission and resolved on dietary therapy alone. Serum erythropoietin was increased on admission and remained elevated during recovery. There was no relationship between serum erythropoietin and Hb concentrations. Key enzymes in the red cell glycolytic and hexose monophosphate pathways and red cell membrane showed increased activity. Red cell ATP concentration was increased and unstable. Red cell K was decreased and, in the fatal cases, red cell Na was increased. The possible significance and practical implications of these findings are discussed.
