Deriving the Turnover Frequency of Aminoxyl-Catalyzed Alcohol Oxidation by Chronoamperometry: An Introduction to Organic Electrocatalysis.
Deriving the Turnover Frequency of Aminoxyl-Catalyzed Alcohol Oxidation by Chronoamperometry: An Introduction to Organic Electrocatalysis.
复制标题
DOI：
10.1021/acs.jchemed.0c01244
复制
发表时间：
2021-02-09
影响因子：
3
通讯作者：
Rafiee M
中科院分区：
文献类型：
--
作者：
Goes SL;Mayer MN;Nutting JE;Hoober-Burkhardt LE;Stahl SS;Rafiee M
有机电合成是一种越来越受欢迎的工具，用于驱动和探测氧化还原反应。该领域的最新进展通常采用电催化剂来提高电化学反应的选择性和效率。本实验以胺催化醇氧化反应为例，向学生介绍电化学中的相关机理技术，以分析电催化反应。本实验室活动采用循环伏安法对催化周转率进行定性评估，然后向学生介绍计时电流法，这是一种未充分利用的技术，有助于定量测定催化速率。学生识别和合理化的可逆电子转移和催化反应的循环伏安图中的重要特征，探测这些痕迹的扫描速率的影响的起源，并使用一系列计时电流图计算周转频率。该方法采用安全和容易获得的试剂：碱性缓冲水溶液，醇底物，和廉价的有机氨氧基催化剂。本文提供的学生数据来自本科生、研究生和药物化学家参加的课程。
Organic electrosynthesis is an increasingly popular tool for driving and probing redox reactions. Recent advances in this field often employ an electrocatalyst to enhance the selectivity and efficiency of electrochemical reactions. A laboratory experiment was developed to introduce students to relevant mechanistic techniques in electrochemistry for analysis of electrocatalytic reactions using aminoxyl-catalyzed alcohol oxidation as a case study. This lab activity employs cyclic voltammetry for qualitative assessment of catalytic turnover prior to introducing students to chronoamperometry, an underutilized technique that facilitates quantitative determination of the rate of catalysis. Students identify and rationalize the important features of reversible electron transfer and a catalytic reaction in a cyclic voltammogram, probe the origin of scan rate effects on these traces, and calculate turnover frequency using a series of chronoamperograms. The method employs safe and readily available reagents: basic aqueous buffer solution, alcohol substrate, and an inexpensive organic aminoxyl catalyst. Student data presented herein were obtained from a course attended by undergraduate students, graduate students, and pharmaceutical chemists.
登录
查看更多内容
影响因子：
62.1
作者：
Nutting JE;Rafiee M;Stahl SS
通讯作者：
Stahl SS
影响因子：
4.5
作者：
ANDRIEUX, CP;BLOCMAN, C;SAVEANT, JM
通讯作者：
SAVEANT, JM
影响因子：
3
作者：
Elgrishi, Noemie;Rountree, Kelley J.;Dempsey, Jillian L.
通讯作者：
Dempsey, Jillian L.
影响因子：
4
作者：
Rafiee, Mohammad;Karimi, Babak;Alizadeh, Saber
通讯作者：
Alizadeh, Saber
影响因子：
3
作者：
King, David;Friend, Jeffrey;Kariuki, James
通讯作者：
Kariuki, James