Massed but not spaced training impairs spatial memory
Massed but not spaced training impairs spatial memory
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DOI：
10.1016/s0166-4328(02)00270-x
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发表时间：
2003-02-17
影响因子：
2.7
通讯作者：
Walsh, D
中科院分区：
文献类型：
--
作者：
Commins, S;Cunningham, L;Walsh, D
Morris水迷宫和物体位移任务是研究空间学习记忆的两种常用工具。研究主要集中在空间任务的获得，而很少注意到保持阶段。我们研究了不同的训练程序对水迷宫的保留和对物体位移任务中空间变化的反应性的影响。我们发现，与那些接受空间训练的动物相比，大量训练的动物在水迷宫的保持上受损。我们还发现，在物体位移任务中，大量训练的动物很容易习惯于它们的环境，而空间训练组则没有。此外，与空间训练组显示的反应性增加相比，大规模训练组在习惯化后7天对空间变化没有反应。结果进行了讨论，在不良的环境编码导致不良的保留。(C)2002 Elsevier Science B.V.保留所有权利。
The Morris water maze and the object displacement task are two popular tools used to investigate spatial learning and memory. Research has focused mainly on the acquisition of spatial tasks while little attention has been given to the retention phase. We examined the effects of different training procedures on retention of the water maze and also reactivity to spatial change in the object displacement task 7 days post-acquisition. We found that massed-trained animals were impaired on retention of the water maze compared to those animals that had received spaced-training. We also found that the massed-trained animals habituated readily to their environment in the object displacement task while the spaced-trained group did not. Furthermore the massed-trained group did not react to spatial change 7 days post-habituation compared to the increased reactivity displayed by the spaced-trained group. Results are discussed in terms of poor encoding of the environment leading to poor retention. (C) 2002 Elsevier Science B.V. All rights reserved.