Association between Tumor Characteristics and Bone Mineral Density in Postmenopausal Breast Cancer Patients.
Association between Tumor Characteristics and Bone Mineral Density in Postmenopausal Breast Cancer Patients.
复制标题
绝经后乳腺癌患者肿瘤特征与骨矿物质密度之间的关联。
DOI：
10.1111/tbj.12141
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Arun,BanuK
中科院分区：
文献类型：
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作者：
Bayraktar,Soley;Avery,Tiffany;Altundag,Kadri;Broglio,Kristine;Arun,BanuK
本研究的目的是评估可手术绝经后乳腺癌患者诊断时的骨密度（BMD）与临床病理结果的关系。158名绝经后妇女进行了基线腰椎和髋部骨密度测量，纳入分析。根据中位骨密度将患者分为两组。P≤0.002被认为具有统计学意义。与使用激素替代疗法（HRT）少于5年的患者相比，使用激素替代疗法（HRT）超过5年与腰椎骨密度增加相关（p = 0.002）。骨密度高的患者往往有低级别疾病，无淋巴血管侵犯，孕激素受体阳性肿瘤，低Ki - 67水平（p < 0.05）。绝经后乳腺癌患者较高的基线骨密度与良好的预后特征相关。
The aim of this study was to evaluate the association of bone mineral density (BMD) at the time of diagnosis with clinical‐pathologic findings in patients with operable postmenopausal breast cancer. One hundred and fifty‐eight postmenopausal women who had a baseline lumbar and hip BMD measurement were included in the analysis. Patients were divided into two groups based on the median BMD. p ≤ 0.002 was considered to be statistically significant. Hormone replacement therapy (HRT) use longer than 5 years was associated with increased lumbar BMD compared with patients who used HRT less than 5 years (p = 0.002). Patients with higher BMD tended to have low grade disease, no lympho‐vascular invasion, progesterone receptor‐positive tumors, and low Ki‐67 levels (p < 0.05). Higher baseline BMD in postmenopausal patients with breast cancer is associated with favorable prognostic features.