Alteration of brain dopamine and serotonin levels in cocaine users: a preliminary report.
Alteration of brain dopamine and serotonin levels in cocaine users: a preliminary report.
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可卡因使用者大脑多巴胺和血清素水平的改变：初步报告。
DOI：
10.1176/ajp.153.9.1216
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Butts,JD
中科院分区：
文献类型：
--
作者：
Little,KY;Patel,UN;Clark,TB;Butts,JD
9名可卡因使用者和9名从未使用过可卡因的对照者的额叶皮层和纹状体中的多巴胺、5-羟色胺及其代谢产物的水平从尸检material.ResultsThe可卡因使用者有显着降低的多巴胺水平和较高的5-羟色胺水平在额叶皮层比对照组。在其他脑区的水平没有显着差异，两组之间。ConclusionsAlterations的多巴胺和5-羟色胺水平可能有助于可卡因戒断和渴望的症状。
MethodLevels of dopamine, serotonin, and their metabolites in the frontal cortex and striatum of nine cocaine users and nine matched control subjects who had never used cocaine were determined from postmortem autopsy material.ResultsThe cocaine users had significantly lower dopamine levels and higher serotonin levels in the frontal cortex than the control subjects. Levels in other brain areas did not differ between the two groups.ConclusionsAlterations of dopamine and serotonin levels might contribute to symptoms of cocaine withdrawal and craving.