Predict disease progression from T-cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection
Predict disease progression from T-cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection
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通过 SIVmac239 感染期间北方猪尾猕猴 (Macaca leonina) 的 T 细胞表型预测疾病进展
DOI：
10.1111/imm.12794
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发表时间：
2017
期刊：
影响因子：
6.4
通讯作者：
Zheng Yong-Tang
中科院分区：
文献类型：
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作者：
Zhang Ming-Xu;Zheng Hong-Yi;Jiang Jin;Song Jia-Hao;Chen Min;Xiao Yu;Lian Xiao-Dong;Song Tian-Zhang;Tian Ren-Rong;Pang Wei;Zheng Yong-Tang
在SIVmac239感染期间，北猪尾猕猴（Macaca leonina, npm）有不同的疾病进展。在本研究中，我们首次分析了SIVmac239感染期间npm中T细胞表型与疾病进展之间的相关性。与正常进展者（NPs）相比，缓慢进展者（SPs）具有较低的慢性T细胞激活和衰竭水平。此外，与NPs相比，SPs具有更高的外周血CD4+T细胞计数和CD4: CD8比值，以及更低的血浆病毒载量。NPs组CD4+T细胞计数和CD4: CD8比值下降较SPs组明显。此外，至少在急性感染中，NPs中的T细胞分化程度高于SPs。这些结果表明，T细胞表型与SIVmac239感染的npm的疾病进展相关，这些相关性可能为改进npm的治疗策略提供有价值的指导。
Macaca leonina(northern pig‐tailed macaques, NPMs) have variable disease progression during SIVmac239 infection. In the present study, we analysed, for the first time, the correlations between T‐cell phenotypes and disease progression in NPMs during SIVmac239 infection. In comparison to normal progressors (NPs), slow progressors (SPs) had lower chronic T‐cell activation and exhaustion levels. In addition, SPs showed higher peripheral CD4+T‐cell count and CD4 : CD8 ratio, and lower plasma viral load than NPs. CD4+T‐cell count and CD4 : CD8 ratio decreased more sharply in NPs than in SPs. Furthermore, T cells in NPs were more highly differentiated, at least in acute infection, than in SPs. These results indicated that T‐cell phenotypes were correlated with disease progression in SIVmac239‐infected NPMs and these correlations may provide valuable guidance for the improvement of therapeutic strategies tested in NPMs.