Extracellular NAD+: a danger signal hindering regulatory T cells
Extracellular NAD+: a danger signal hindering regulatory T cells
复制标题
DOI：
10.1016/j.micinf.2012.05.011
复制
发表时间：
2012-11-01
影响因子：
5.8
通讯作者：
Koch-Nolte, Friedrich
中科院分区：
文献类型：
--
作者：
Adriouch, Sahil;Haag, Friedrich;Koch-Nolte, Friedrich
细胞损伤时释放的内源性危险信号有助于提醒免疫系统。通常，它们的释放导致先天免疫细胞的活化和成熟，以及促炎细胞因子的产生。此外，细胞外NAD（+）通过阻碍调节性T细胞（Tcells）刺激免疫反应，因此可能代表了一类新的危险信号的原型。(C)2012巴斯德研究所。由Elsevier Masson SAS出版。All rights reserved.
Endogenous danger signals released during cell damage contribute to alert the immune system. Typically, their release results in the activation and maturation of innate immune cells, and the production of pro-inflammatory cytokines. In addition, extracellular NAD(+) stimulates immune responses by hindering regulatory T cells (Tregs), and could, therefore, represent the prototype of a new category of danger signals. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.