Tumor necrosis factor-α-converting enzyme (TACE) levels in periodontal diseases
Tumor necrosis factor-α-converting enzyme (TACE) levels in periodontal diseases
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DOI：
10.1177/154405910808700311
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发表时间：
2008-03-01
影响因子：
7.6
通讯作者：
Belibasakis, G. N.
中科院分区：
文献类型：
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作者：
Bostanci, N.;Emingil, G.;Belibasakis, G. N.
肿瘤坏死因子-α-转化酶（TACE）是一种金属蛋白酶，可从细胞膜上脱落几种细胞因子，包括NF-κ B配体受体激活剂（RANKL）。本研究的目的是调查的假设，TACE将升高的龈沟液（GCF）的人与牙周炎。慢性和侵袭性牙周炎患者GCF中的总TACE量高于牙龈炎或健康人。在GCF TACE浓度较高的慢性和侵袭性牙周炎的人比牙龈炎，虽然没有显着高于健康人。接受免疫抑制治疗的慢性牙周炎患者的TACE水平比其他牙周炎组低10倍以上。TACE与探入囊袋深度、临床附着水平和GCF中RANKL浓度呈正相关。总之，牙周炎患者GCF TACE水平升高及其与RANKL的正相关性可能表明该酶与牙槽骨丢失相关，在未来的治疗方法中可能需要特别关注。
Tumor necrosis factor-alpha- converting enzyme ( TACE) is a metalloprotease which can shed several cytokines from the cell membrane, including receptor activator of NF-kappa B ligand ( RANKL). This study aimed to investigate the hypothesis that TACE would be elevated in the gingival crevicular fluid ( GCF) of persons with periodontitis. Total TACE amounts in GCF were higher in persons with chronic and aggressive periodontitis than in those with gingivitis or in healthy persons. TACE concentrations in GCF were higher in persons with chronic and aggressive periodontitis than in those with gingivitis, although not significantly higher than in healthy persons. Persons with chronic periodontitis receiving immunosuppressive treatment exhibited over 10-fold lower TACE levels than the other periodontitis groups. TACE was positively correlated with probing pocket depth, clinical attachment levels, and RANKL concentrations in GCF. In conclusion, the increased GCF TACE levels in persons with periodontitis and their positive correlation with RANKL may indicate an association of this enzyme with alveolar bone loss, and may warrant special attention in future therapeutic approaches.