Inducible expression of insulin receptors on T lymphocyte clones.
Inducible expression of insulin receptors on T lymphocyte clones.
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DOI：
10.1084/jem.156.2.664
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发表时间：
1982-08-01
期刊：
影响因子：
--
通讯作者：
Braciale TJ
中科院分区：
文献类型：
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作者：
Braciale VL;Gavin JR 3rd;Braciale TJ
本研究证明，某些T细胞克隆经特异性抗原刺激后，其表面可表达胰岛素受体。这些淋巴细胞上的胰岛素受体在物理化学上类似于存在于细胞(脂肪细胞、肝细胞等)上的胰岛素受体。克隆的非细胞毒性T细胞在特异性抗原刺激后胰岛素受体的表达动力学与培养物中[~3H]胸腺嘧啶核苷掺入的动力学非常相似。
This study demonstrates that the insulin receptors are expressed on the surface of some T cell clones after specific antigenic stimulation. The insulin receptors on these lymphocytes are physicochemically similar to insulin receptors present on cells which express the receptors constitutively (adipocytes, hepatocytes, etc.). The kinetics of expression of insulin receptors on cloned, noncytotoxic T cells after specific antigenic stimulation closely parallels that of [3H]thymidine incorporation in such cultures.