Prenatal and childhood adversity and inflammation in children: A population-based longitudinal study
Prenatal and childhood adversity and inflammation in children: A population-based longitudinal study
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DOI：
10.1016/j.bbi.2020.01.024
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发表时间：
2020-07-01
影响因子：
15.1
通讯作者：
Lewis, Glyn
中科院分区：
文献类型：
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作者：
Flouri, Eirini;Francesconi, Marta;Lewis, Glyn
背景：儿童时期经历的应激性生活事件和早期产前发育与儿童时期的炎症有关。然而，还没有研究同时考虑这两种暴露，或者研究它们相互作用的影响。方法：在雅芳父母和儿童纵向研究中，我们探讨了9岁时的炎症标志物[血清C反应蛋白（CRP）和白细胞介素6（IL-6）]是否与早期产前事件有关（在怀孕18周时），儿童期事件（在0-9岁时测量7次）及其相互作用（n= 3，915）。潜伏生长曲线模型估计儿童期事件的轨迹，线性回归探讨产前和儿童期事件与炎症标志物的关联。模型控制种族，社会经济地位和体重指数，按性别分层，并考虑未加权和加权（影响）事件exposs.Results：即使调整后的混杂因素和产前事件，截距和斜率的儿童事件的数量与IL-6，但仅在女性。斜率的显著影响适用于加权（按影响）和未加权事件规范。当控制儿童期事件时，产前事件与任一炎症标志物均不相关。有没有证据的协同效应的产前和儿童events.Conclusion：独立的产前不良生活事件，在儿童时期经历的不良生活事件的数量和数量的增加与炎症标志物，如IL-6，在女孩的血浆水平呈正相关。这种性别特异性值得进一步研究。
Background: Stressful life events experienced during childhood and early prenatal development have been associated with inflammation during childhood. However, no study has considered these two exposures jointly, or has investigated the effect of their interaction.Methods: In the Avon Longitudinal Study of Parents and Children, a general-population birth cohort, we explored if inflammatory markers [serum C-reactive protein (CRP) and interleukin 6 (IL-6)] at age 9 years were related to early prenatal events (at 18 weeks pregnancy), childhood events (measured on seven occasions at ages 0-9 years) and their interaction (n=3,915). Latent growth curve modelling estimated trajectories of childhood events, and linear regression explored associations of prenatal and childhood events with inflammatory markers. Models controlled for ethnicity, socioeconomic status and body mass index, were stratified by gender and considered both unweighted and weighted (by impact) event exposures.Results: Even after adjustment for confounders and prenatal events, both the intercept and the slope of number of childhood events were associated with IL-6, but only in females. The significant effect of the slope held for both weighted (by impact) and unweighted event specifications. Prenatal events were not associated with either inflammatory marker when childhood events were controlled. There was no evidence for synergistic effects of prenatal and childhood events.Conclusion: Independently of prenatal adverse life events, the number and increase in number of adverse life events experienced in childhood were associated positively with plasma levels of inflammatory markers, such as IL-6, in girls. This gender specificity warrants further research.