SYNTHESIS OF 2 COMPONENTS OF HUMAN-COMPLEMENT, BETA-1H AND C3BINA, DURING FETAL LIFE
SYNTHESIS OF 2 COMPONENTS OF HUMAN-COMPLEMENT, BETA-1H AND C3BINA, DURING FETAL LIFE
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DOI：
10.1111/j.1651-2227.1981.tb05772.x
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
BRADWELL, AR
中科院分区：
文献类型：
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作者：
ADINOLFI, M;DOBSON, NC;BRADWELL, AR
对人胎儿、脐带和母体的血清中β1H[球蛋白]和C3bINA[补体成分3灭活物]的水平进行了评估。在12周以上的胎儿中检测到补体(C)的两种成分。血药浓度有随胎龄增加而升高的趋势。脐带血中β1H和C3bINA的平均值分别接近正常成人血清平均值的54%和61%。在妊娠期结束时，母血中β-1H水平升高。将β1H和C3bINA水平与其他两个C水平进行比较，证实胎儿和新生儿血清中C9的平均水平较低；母体样本中C9和B因子的浓度较高。通过标记氨基酸的掺入和琼脂凝胶中特异性免疫沉淀物的放射自显影，在胎肝和腹膜细胞的培养液中检测到新合成的β1H。
The levels of .beta.1H [globulin] and C3bINA [complement component 3 inactivator] were estimated in sera from human fetuses, cord and maternal samples. Both components of complement (C) were detected in fetuses more than 12 wk old. The serum concentrations tended to increase with the gestational age. The mean levels of .beta.1H and C3bINA in cord sera were near 54 and 61% of the mean values in sera from normal adults. Elevated levels of .beta.1H wereobserved in maternal sera at the end of the gestational period. When the levels of .beta.1H and C3bINA were compared with those of 2 other C, it was confirmed that the mean levels of C9 were low in fetal and newborn sera; the serum concentrations of C9 and Factor B were elevated in maternal samples. Newly synthesized .beta.1H was detected in the culture fluids of fetal liver and peritoneal cells, as judged by the incorporation of labeled amino acids and the autoradiography of the specific immunoprecipitates in agar gel.