Pleiotropy as the Mechanism for Evolving Novelty: Same Signal, Different Result.
Pleiotropy as the Mechanism for Evolving Novelty: Same Signal, Different Result.
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DOI：
10.3390/biology4020443
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发表时间：
2015-06-19
期刊：
影响因子：
4.2
通讯作者：
Torday JS
中科院分区：
文献类型：
--
作者：
Torday JS
与将多效性视为产生两个或更多不同表型性状的单个基因的随机表达的概率方法相反，它实际上是复杂生理从单细胞状态进化的确定性结果。多效性的新颖性是在生殖过程中根据过去和现在的物理和生理条件对细胞-细胞信号进行重新组合和排列，以服务于有机体未来继续生存的需要。从肺到肾、皮肤、脑、甲状腺和脑下垂体的功能同源都是多效性进化机制策略的例证。这一观点的力量体现在进化渐进主义和断断续续的均衡的解决上，与尼尔斯·玻尔解决光作为互补的矛盾二元性的方式大致相同。
In contrast to the probabilistic way of thinking about pleiotropy as the random expression of a single gene that generates two or more distinct phenotypic traits, it is actually a deterministic consequence of the evolution of complex physiology from the unicellular state. Pleiotropic novelties emerge through recombinations and permutations of cell-cell signaling exercised during reproduction based on both past and present physical and physiologic conditions, in service to the future needs of the organism for its continued survival. Functional homologies ranging from the lung to the kidney, skin, brain, thyroid and pituitary exemplify the evolutionary mechanistic strategy of pleiotropy. The power of this perspective is exemplified by the resolution of evolutionary gradualism and punctuated equilibrium in much the same way that Niels Bohr resolved the paradoxical duality of light as Complementarity.