Brain natriuretic peptide release in acute myocardial infarction
Brain natriuretic peptide release in acute myocardial infarction
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DOI：
10.17305/bjbms.2012.2470
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发表时间：
2012-08-01
影响因子：
3.4
通讯作者：
Zvizdic, Faris
中科院分区：
文献类型：
--
作者：
Durak-Nalbantic, Azra;Dzubur, Alen;Zvizdic, Faris
由于心室肌细胞的伸展和容量超负荷，脑钠尿肽 (BNP) 会从心室肌细胞中释放出来。心力衰竭时会释放 BNP。本研究的目的是观察急性心肌梗塞 (AMI) 中 BNP 的释放。我们测量了 75 名 AMI 患者的 BNP。对照组 (n=61) 的年龄和性别与 AMI 组相似。我们发现与对照组相比，BNP 显着升高（462.875 pg/ml vs 35.356 pg/ml，p < 0.001）。严重收缩功能障碍患者 BNP 水平最高，收缩功能保留患者 BNP 水平最低（EF < 30% 组 BNP = 1129.036 pg/ml VS EF31-40% 组 BNP = 690.177 pg/ml VS EF 41-50% 组 BNP = 274.396 pg/ml VS EF 41-50% 组 BNP = 274.396 pg/ml EF > 51% BNP = 189.566 pg/ml，p < 0.001）。我们发现 BNP 与左心室舒张末期内径 (LVDd) 之间存在统计学上显着的轻度正相关性 (r = 0.246，p < 0.05)。 BNP 与肌钙蛋白峰值水平之间的真实正相关性 (r = 0.441，p < 0.05)。与下分配相比，AMI 前间隔分配的 BNP 水平较高（835.80 pg/ml vs 243.03 pg/ml，p < 0.001），并且接受肝素治疗的患者与纤溶治疗患者相比（507.885 pg/ml vs 354.73 pg/ml，p < 0.05）。 定量生化标志物与梗塞程度和左心室收缩功能障碍相关。除了超声心动图计算外，BNP 升高还可用于快速、轻松地确定左心室收缩功能障碍。 (C) 2012 年 FBOH 基础医学协会。版权所有
Brain natriuretic peptide (BNP) is released from ventricular myocites due to their stretching and volume overload. In heart failure there is BNP release. Aim of this study was to observe BNP release in acute myocardial infarction (AMI).We measured BNP in 75 patients with AMI. Control group (n=61) was similar by age and gender to AMI group.We found statistically significant elevation of BNP compared to controls (462.875 pg/ml vs 35.356 pg/ml, p < 0.001). Patients with severe systolic dysfunction had the highest BNP levels, while patients with the preserved systolic function had the lowest BNP levels (Group with EF < 30% BNP = 1129.036 pg/ml VS Group with EF31-40% BNP = 690.177 pg/ml VS Group with EF 41-50% BNP = 274.396 pg/ml VS Group with EF > 51% BNP = 189.566 pg/ml, p < 0.001). We found statistically significant light positive correlation between BNP and left ventricle end-diastolic diameter (LVDd) (r = 0.246,p < 0.05). and real positive correlation between BNP and peak troponin levels (r = 0.441,p < 0.05). BNP levels were higher in anteroseptal allocation of AMI compared to inferior allocation (835.80 pg/ml vs 243.03 pg/ml, p < 0.001) and in patients who were treated with heparin compared to fibrinolitic therapy (507.885 pg/ml vs 354.73 pg/ml, p < 0.05).BNP is elevated in AMI and is a quantitative biochemical marker related to the extent of infarction and the left ventricle systolic dysfunction. Besides echocardiographic calculation, elevation of BNP could be used for quick and easy determination of the left ventricle systolic dysfunction. (C) 2012 Association of Basic Medical Sciences of FBOH. All rights reserved